Mammary Cell News Volume 15.25 | June 29 2023

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    Noshin Noorjahan
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    2023-06-29 | MCN 15.25


    Mammary Cell News by STEMCELL Technologies
    Vol. 15.25 – 29 June, 2023
    TOP STORY

    Glucose-Induced CRL4COP1-p53 Axis Amplifies Glycometabolism To Drive Tumorigenesis

    Scientists described a glucose-signaling axis that reinforced glucose uptake and glycolysis to consolidate the Warburg effect and overcome tumor suppression.
    [Molecular Cell]

    AbstractGraphical Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    Hypoxia Induced Responses Are Reflected in the Stromal Proteome of Breast Cancer

    Researchers studied breast cancer hypoxia responses, focusing on secreted proteins from luminal-like and basal-like cell lines before and after hypoxia.
    [Nature Communications]

    Full Article

    Abemaciclib Is Effective in Palbociclib-Resistant Hormone Receptor-Positive Metastatic Breast Cancers

    The authors generated multiple in vitro models of palbociclib-resistant and abemaciclib-resistant cell lines, as well as in vivo patient-derived xenografts (PDX) and ex vivo PDX-derived organoids from patients who progressed on cyclin-dependent-kinase-4/6 inhibitor.
    [Cancer Research]

    Abstract

    Loss of Function of GATA3 Regulates FRA1 and c-FOS To Activate EMT and Promote Mammary Tumorigenesis and Metastasis

    Investigators reported that haploid loss of Gata3 in mice lacking p18Ink4c, a cell cycle inhibitor, up-regulated Fra1and downregulated c-Fos leading to activation of epithelial-mesenchymal transition and promotion of mammary tumor initiation and metastasis.
    [Cell Death & Disease]

    Full Article

    Non-POU Domain-Containing Octomer-Binding (NONO) Protein Expression and Stability Promotes the Tumorigenicity and Activation of Akt/MAPK/β-Catenin Pathways in Human Breast Cancer Cells

    Scientists reported that NONO protein was overexpressed in breast cancer and validated the interaction of the WW domain of PIN1 with c-terminal threonine-proline motifs of NONO.
    [Cell Communication and Signaling]

    Full Article

    Chemotherapy-Induced Executioner Caspase Activation Increases Breast Cancer Malignancy through Epigenetic De-Repression of CDH12

    Mechanistically, cadherin 12 (CDH12) was persistently upregulated in anastatic cells and promotes breast cancer malignancy via activation of ERK and CREB.
    [Oncogenesis]

    Full Article

    Spatial Topology of Organelle Is a New Breast Cancer Cell Classifier

    Investigators developed an organelle topology-based cell classification pipeline, which integrated artificial intelligence and imaging quantification to analyze organelle spatial distribution and inter-organelle topology.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Association of Quantitative Analysis of Intratumoral Reduced E-Cadherin Expression with Lymph Node Metastasis and Prognosis in Patients with Breast Cancer

    Researchers investigated the association of reduced E-cadherin expression with adipose tissue invasion and prognosis in breast cancer.
    [Scientific Reports]

    Full Article

    Aurora Kinase A Regulates Cancer-Associated RNA Aberrant Splicing in Breast Cancer

    Scientists showed that oncogenic aurora kinase A promoted breast cancer-related RNA aberrant splicing in a context-dependent manner.
    [Heliyon]

    Full Article
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    REVIEWS

    Incorporating Clinicopathological and Molecular Risk Prediction Tools To Improve Outcomes in Early HR+/HER2– Breast Cancer

    The authors examine the evidence for clinicopathological and molecular risk prediction tools in clinical practice and offer a perspective of potential future risk stratification strategies in the setting of hormone receptor–positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-) early breast cancer.
    [npj Breast Cancer]

    Full Article
    INDUSTRY AND POLICY NEWS

    Susan G. Komen® Announces 2023 Grants To Accelerate Research Discoveries and Improve Outcomes for Breast Cancer Patients

    Susan G. Komen® announced the awarding of 49 new grants to researchers at 28 leading institutions in the US. The $19.3 million in new grants support Komen’s mission to end breast cancer.
    [Susan G. Komen]

    Press Release
    FEATURED EVENT

    2023 Hormone-Dependent Cancers Conference GRC

    August 6 – 11, 2023
    Newry, Maine, United States

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellowship – Cancer Research

    Ume̴ University РUme̴, Sweden

    Higher Scientific Officer – Proteomics

    Institute of Cancer Research – London, England, United Kingdom

    Breast Pathologist – Pathology

    University of Vermont – Burlington, Vermont, United States

    Research Associate – Bioinformatics

    The University of British Columbia – Vancouver, British Columbia, Canada

    Postdoctoral Scholar – Cancer Research

    The University of Tennessee Health Science Center – Memphis, Tennessee, United States

    > See All Jobs

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