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Pulmonary Cell News| Mesenchymal Cell News 10.26 July 3, 2018 | |
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TOP STORYInvestigators identified that CD90 marks a rare adventitial population that co-expresses MSC markers including PDGFRα, CD44, CD73, and CD105. Human adventitial CD90+ cells fulfilled standard MSC criteria, including plastic adherence, spindle morphology, passage ability, colony formation, and differentiation into adipocytes, osteoblasts, and chondrocytes. [Stem Cell Reports] Full Article | Press Release | |
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PUBLICATIONS(Ranked by impact factor of the journal)IN VITROThe Interferon-Inducible Protein p202 Promotes Osteogenesis in Mouse Bone Marrow Stromal Cells Both the mRNA and protein levels of p202 increased initially and decreased afterward in the course of bone marrow stromal cell osteogenesis. The authors revealed that p202 disturbed the formation of Runx2/Ids complex and freed Runx2 to induce the differentiation process. [Biosci Rep] Full Article Oxidative stress was induced by treating porcine adipose-derived mesenchymal stem cells (pASCs) with 500 μM hydrogen peroxide with or without vitamin E. Gene expression analysis of vitamin E-treated pASCs showed down-regulated expression for the genes associated with oxidative stress and apoptosis. [Cell Tissue Res] Abstract Researchers evaluated the diffusion capacity and the biological effects of different bleaching products on human dental pulp stem cells. The bleaching gel was applied for 90, 30 or 15 min to enamel/dentine discs that adapted in an artificial chamber. [Materials (Basel)] Full Article miR-377-3p expression was markedly decreased during adipogenic differentiation of human MSCs (hMSCs). Expression of LIFR markedly increased during adipogenic differentiation of hMSCs. Results indicated that miR-377-3p bound directly to the 3′-untranslated region of LIFR. [Mol Cell Biochem] Abstract IN VIVOInvestigators developed new electrospun nanofibers, made of poly (ε-caprolactone)/polytetrahydrofuran (PCL-PTHF urethane) and collagen I from calf skin, to trigger the chondrogenic differentiation of mesenchymal stem cells the cartilage regeneration in vivo. [Biomaterials] Abstract In vivo experiments revealed that human dental pulp stem cells stably expressing Myc-peroxiredoxin 6 (PRDX6) suppressed hDPSC-based bone regeneration in calvarial defect mice, and newborn PRDX6 transgenic mice exhibited delayed bone development and reduced RUNX2 expression. [Antioxid Redox Signal] Abstract Compared to normal control subjects (N-PDLSCs), periodontitis patients (P-PDLSCs) were less capable of forming cell aggregates, and P-PDLSC aggregates showed impaired osteogenesis and regeneration. In both N-PDLSCs and P-PDLSCs, resveratrol promoted cell aggregate formation and improved their osteogenic potential. [Exp Mol Med] Full Article Mesenchymal Stem Cells in Combination with Hyaluronic Acid for Articular Cartilage Defects Researchers investigated the therapeutic effects of bone marrow MSCs combined with hyaluronic acid (HA) on articular cartilage repair in canines. MSCs plus HA regenerated more cartilage-like tissue than did HA alone or saline. [Sci Rep] Full Article Scientists investigated the systemic administration of extracellular vesicles derived from human umbilical cord mesenchymal stem cells (UCMSCs-EVs) as a therapeutic agent for intrauterine adhesions caused by endometrial injury. They investigated the therapeutic impact of both UCMSCs-EVs and estrogen either separately or in combination in a rat model. [Stem Cell Res Ther] Full Article The cell adhesion and homing assay revealed that pericellular collagen I coating facilitated MSCs adhesion on cartilage slices, enhancing MSC homing and retention to cartilage defect. This increased homing ratio was accompanied by increased cell-cell contact. [Stem Cell Res Ther] Full Article The mRNA expression of brain-derived neurotrophic factor and nerve growth factor was significantly stronger in rat cranial bone-derived MSCs (rcMSC) than in rat bone marrow-derived MSCs (rbMSC). Ischemic stroke model rats in the rcMSC transplantation group showed better functional recovery than those in the no transplantation and rbMSC transplantation groups. [Stem Cells Dev] Abstract Subscribe to one of our other 19 science newsletters such as ESC & iPSC News & Cell Therapy News. | |
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REVIEWSThe authors discuss the preclinical and clinical findings of Mesenchymal stromal cells (MSCs) in sepsis. They review the characteristics of EVs and MSC-derived extracellular vesicles (MSC-EVs). Finally, they present the evidence that MSC-EVs are effective in treating models of sepsis. [Cell Tissue Res] Abstract Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field. | |
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INDUSTRY NEWSGovernment Announces £215m Investment in NHS Health Research The government has announced an investment of £215 million to fund NHS health research aiming to “transform the lives” of millions of people living with a range of conditions. [PharmaTimes] Press Release BioAtla, LLC announced the treatment of the first patient in its clinical trial BA3021-001 for BioAtla’s BA3021, a novel conditionally active ROR2-targeted antibody-drug conjugate (CAB-ROR2-ADC). [BioAtla, LLC] Press Release | |
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POLICY NEWSEurope’s Biggest Research Fund Cracks Down on ‘Ethics Dumping’ Ethics dumping — doing research deemed unethical in a scientist’s home country in a foreign setting with laxer ethical rules — will be rooted out in research funded by the European Union, officials announced. [Nature News] Editorial U.S. Lawmakers Want NIH and CDC Foundations to Say More about Donors A key congressional spending panel has fired a shot across the bow of two federally chartered medical foundations, warning that the way they disclose information about donors may not pass muster. [ScienceInsider] Editorial Geneticist Francisco Ayala Quits after Sexual Harassment Accusations An investigation by the University of California, Irvine, has concluded that one of its most famous faculty members, geneticist Francisco Ayala, sexually harassed colleagues and a student. Ayala resigned as of July 1 and the school will remove his name from the School of Biological Sciences, the central science library, scholarships, and endowed chairs. [The Scientist] Editorial
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EVENTSNEW Connective Tissue Oncology Society (CTOS) 2018 Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESNEW Senior Lecturer – Stromal Immunology (University of Aberdeen) NEW Research Assistant – Synthetic Scaffolds for Tendon Repair (University of Oxford) NEW Faculty Position – Cellular Physiology and Engineering (Mayo Clinic) Research Fellow – Stem Cell Biology and Engineering (New York Blood Center) Research Assistant – Cell Culture and Engineering (University of Oxford) Experimental Postdoctoral Position – Single-Cell Functional Genomics (Heidelberg University) Postdoctoral Positions – Cell Biology (Children’s Hospital of Philadelphia) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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