Mesenchymal Cell News Volume 12.04 | Feb 4 2020

TOP STORY

Unidirectional Rotating Molecular Motors Dynamically Interact with Adsorbed Proteins to Direct the Fate of Mesenchymal Stem Cells

Researchers showed that the signaling effects of the molecular motion were mediated by the adsorbed cell-instructing protein layer, influencing the focal adhesion-cytoskeleton actin transduction pathway and regulating the protein and gene expression of human bone marrow-derived-MSCs. [Sci Adv] Abstract | Press Release

(Ranked by impact factor of the journal)

IN VITRO

Mitochondrial Transfer from MSCs to T Cells Induces Treg Differentiation and Restricts Inflammatory Response

Scientists explored the effect of MSC‐mediated transfer of mitochondria (MitoT) on lymphoid cells. They describe dose‐dependent MitoT from mitochondria‐labeled MSCs mainly to CD4⁺ T cells, rather than CD8⁺ T cells or CD19⁺ B cells. [EMBO J] Abstract

Ascorbate and Iron Are Required for the Specification and Long-Term Self-Renewal of Human Skeletal Mesenchymal Stromal Cells

Using a stepwise and chemically defined system to derive lateral mesoderm progenitors from human pluripotent stem cells (hPSCs), investigators found that ascorbate increased the expression of MSC markers, purity of MSCs, the long-term self-renewal and osteochondrogenic capacity of hPSC-MSCs in vitro. [Stem Cell Reports] Full Article

AICAR and Nicotinamide Treatment Synergistically Augment the Proliferation and Attenuate Senescence-Associated Changes in Mesenchymal Stromal Cells

To slow down the senescence of MSCs, scientists evaluated the in vitro effects of 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), an AMPK activator, and nicotinamide, an activator of sirtuin1. [Stem Cell Res Ther] Full Article

Islet-1 Synergizes with Gcn5 to Promote MSC Differentiation into Cardiomyocytes

Researchers found that the key enzymes that regulate GATA4/Nkx2.5 expression are Gcn5/HDAC1, G9A, and DNMT-1. When α-methylene-γ-butyrolactone 3 was used to inhibit Gcn5 expression, they observed that the interactions among these key enzymes in the GATA4/Nkx2.5 promoters were blocked, and MSCs could not be induced into cardiomyocytes. [Sci Rep] Full Article

IN VIVO

Schnurri-3 Regulates BMP9-Induced Osteogenic Differentiation and Angiogenesis of Human Amniotic Mesenchymal Stem Cells through Runx2 and VEGF

The authors conducted a comprehensive study to identify the effect of Schnurri-3 on BMP9-induced osteogenic differentiation and angiogenesis in human amniotic MSCs and analyzed the responsible signaling pathway. [Cell Death Dis] Full Article

Bone Marrow Mesenchymal Stem Cells Enhance Autophagy and Help Protect Cells under Hypoxic and Retinal Detachment Conditions

The cellular morphology, viability, apoptosis and autophagy of hypoxic 661w cells and cells cocultured with BMSCs were analyzed. In retinal detachment model, BMSCs were intraocularly transplanted, and then, the retinal morphology, outer nuclear layer thickness and rhodopsin expression were studied as well as apoptosis and autophagy of the retinal cells. [J Cell Mol Med] Full Article

Platelet-Derived Microparticles Mediate the Intra-Articular Homing of Mesenchymal Stem Cells in Early-Stage Cartilage Lesions

The optimal homing time of synovium-derived MSCs (SMSCs) was determined by evaluating the SMSCs’ homing efficiency at 1, 3, 7, 14, and 28 days after injury using a rat cartilage defect model. The ability of platelet-derived microparticles to promote SMSC homing was evaluated by cartilage/subchondral bone cell adhesion, transmembrane migration and intra-articular cell distribution assays. [Stem Cells Dev] Abstract

Upregulation of MicroRNA‐200a in Bone Marrow Mesenchymal Stem Cells Enhances the Repair of Spinal Cord Injury in Rats by Reducing Oxidative Stress and Regulating Keap1/Nrf2 Pathway

Researchers explored the effects of lentivirus‐mediated miR‐200a gene‐modified bone marrow MSC transplantation on the repair of spinal cord injury in a rat model. [Artif Organs] Abstract

Subscribe to one of our other 19 science newsletters such as ESC & iPSC News & Cell Therapy News.

Eph/ephrin Signaling and Biology of Mesenchymal Stromal/Stem Cells

The authors review the current evidence on the relationships between Eph kinase receptors, their ephrin ligands, and MSCs. [J Clin Med] Abstract | Download Full Article

Visit our reviews page to see a complete list of reviews in the mesenchymal cell research field.

Avacta and Daewoong Agree Collaboration and License Agreement with AffyXell Therapeutics

Avacta Group plc announced that it has signed a collaboration and license agreement with AffyXell Therapeutics to develop Affimer proteins to be used by AffyXell for the generation of new cell and gene therapies. [Avacta Group plc] Press Release

BrainStorm Receives Notice of Intention to Grant Additional EU patent for NurOwn^®

BrainStorm Cell Therapeutics, Inc. announced that the European Patent Office has communicated its intention to grant a European patent titled ‘Methods of Generating Mesenchymal Stem Cells which Secrete Neurotrophic Factors’. [BrainStorm Cell Therapeutics, Inc.] Press Release

Cash from Cannabis Companies Creates Conflicted Researchers

Imagine that scientists charged with doing research on tobacco’s health implications were funded by tobacco companies. In fact, the tobacco industry used this tactic for decades to cast doubt on the adverse health effects of smoking. But today it would be an outrageous conflict of interest – research on addictive drugs shouldn’t be paid for by people who stand to profit from selling them. Yet this is exactly what is happening with cannabis. [STAT News] Editorial

Chan Zuckerberg Initiative to Fund 30 Patient Groups, Aiming to Build a Model for Tackling Rare Diseases

On January 3^rd, Mark Zuckerberg and his spouse Dr. Priscilla Chan’s philanthropic vehicle announced a set of grants that executives there hope will create a model for tackling any rare disease: financing patient-led groups, and giving them training and resources. [STAT News] Editorial

NEW First International STEMNET Meeting
May 6-8, 2020
Padua, Italy

Visit our events page to see a complete list of events in the community.

NEW Senior Research Scientist or Postdoctoral Fellow – Sarcoma Biology (Memorial Sloan Kettering Cancer Center)

NEW Postdoctoral Research Fellowship – Autism Disease Modeling (Black Family Stem Cell Institute)

Postdoctoral Fellowship – Stem Cell Niche Biology (University of California, San Francisco)

Postdoctoral Fellow – Cardiovascular Research (Temple University)

Postdoctoral Associate – Cartilage Regeneration (Drexel University)

Postdoctoral Scholar – Corneal Stem Cells (University of California, Los Angeles)

Senior Research Technician – Stem Cell Biology (Columbia University in the City of New York)

PhD Positions – Cell Biology (University of Warwick)

Postdoctoral Positions – Cell and Molecular Biology (University of Copenhagen)

Postdoctoral Positions – Drug Delivery and Therapeutic Development (University of Minnesota)

Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.

Have we missed an important article or publication in Mesenchymal Cell News? Click here to submit!

Comments or suggestions? Submit your feedback here.