Mesenchymal Cell News Volume 7.20 | May 26 2015

miR-148a Is Associated with Obesity and Modulates Adipocyte Differentiation of Mesenchymal Stem Cells through Wnt Signaling
Researchers examined the roles of adipocyte-selective microRNAs (miRNAs) in the differentiation of human adipose-derived mesenchymal stem cells (hMSCs-Ad) to adipocytes. They showed that the levels of miR-148a, miR-26b, miR-30, and miR-199a increased in differentiating hMSCs-Ad. [Sci Rep] Full Article

Influence of Erythropoietin on Microvesicles Derived from Mesenchymal Stem Cells Protecting Renal Function of Chronic Kidney Disease
Investigators studied the influence of erythropoietin on microvesicles derived from mesenchymal stem cells, and the protective effects of these factors in subjects with chronic kidney disease [Stem Cell Res Ther] Abstract | Full Article

Mesenchymal Stem Cells Derived from Peripheral Blood Retain their Pluripotency but Undergo Senescence during Long-Term Culture
The authors triggered production of peripheral blood-derived mesenchymal stem cells (PB-MSCs) in rabbits using G-CSF and AMD3100, and then isolated and expanded the cells in culture until they reached a state of senescence, usually after about 20 passages. [Tissue Eng Part C Methods] Abstract

Isolation and Characterization of Mesenchymal Stem/Stromal Cells in the Ovine Endometrium
In preparation for developing a large animal preclinical model for urological and gynecological tissue engineering applications researchers aimed to identify and characterize mesenchymal stem/stromal cells in ovine endometrium and determine surface markers to enable their prospective isolation. [PLoS One] Full Article

Capsaicin Inhibits the Adipogenic Differentiation of Bone Marrow Mesenchymal Stem Cells by Regulating Cell Proliferation, Apoptosis, Oxidative and Nitrosative Stress
Scientists analyzed whether capsaicin is capable of inhibiting the differentiation of bone marrow mesenchymal stem cells (BMSCs) to adipocytes. BMSCs were obtained and exposed to different concentrations of capsaicin for a period of six days following two days of adipogenic induction. [Food Funct] Abstract

Human Mesenchymal Stem Cells Enhance Cancer Cell Proliferation via IL-6 Secretion and Activation of ERK1/2
Researchers evaluated the effects of human mesenchymal stem cells (hMSC) on head and neck squamous cell carcinoma cell lines (FaDu and HLaC78) in vitro. hMSC released several cytokines and growth factors. FaDu and HLaC78 showed a significant enhancement of cell proliferation after cultivation with hMSC-conditioned medium as compared to control. [Int J Oncol] Abstract

Apigenin Promotes Osteogenic Differentiation of Human Mesenchymal Stem Cells through JNK and p38 MAPK Pathways
The effect of apigenin on osteogenic differentiation of human mesenchymal stem cells (hMSCs) was explored. Scientists showed that apigenin treatment significantly increased alkaline phosphatase activity and mineralization in hMSCs. [Mol Cell Biochem] Abstract

Enhancement of Human Mesenchymal Stem Cell Infiltration into the Electrospun Poly(Lactic-co-Glycolic Acid) Scaffold by Fluid Shear Stress
Scientists investigated the directional migration of human mesenchymal stem cells and infiltration into poly(lactic-co-glycolic acid) scaffold by fluid shear stress. The human mesenchymal stem cells showed directional migrations following the direction of the flow. [Biochem Biophys Res Commun] Abstract

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Cancer Prevention and Research Institute of Texas Awards 41 New Grants
The Cancer Prevention and Research Institute of Texas awarded 28 grants through its academic research program, 11 grants through its prevention program and two grants through its product development research program. [Cancer Prevention and Research Institute of Texas] Press Release

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NEW Postdoctoral Fellow – Stem Cell Biology and Pharmacogenomics (Northwestern University)

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Faculty Positions – Stem Cell & Regenerative Medicine (The University of Texas Medical School at Houston)

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