Muscle Cell News Volume 10.01 | Jan 20 2025

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    Jamie Kang
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    2025-01-20 | MUSCN 10.01


    Muscle Cell News by STEMCELL Technologies
    Vol. 10.01 – 20 January, 2025
    TOP STORY

    Human Epicardial Organoids from Pluripotent Stem Cells Resemble Fetal Stage with Potential Cardiomyocyte- Transdifferentiation

    After eight-days treatment of TGF-beta following by bFGF, cells entered into epithelium-mesenchymal transition and gave rise to smooth muscle cells. Epicardium could also integrate and invade into mouse heart with SNAI1 expression, and give birth to numerous cardiomyocyte-like cells.
    [Cell & Bioscience]

    Full Article
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    PUBLICATIONSListed by the impact factor of the journal

    Impaired Hydrogen Sulfide Biosynthesis Underlies Eccentric Contraction-Induced Force Loss in Dystrophin-Deficient Skeletal Muscle

    Researchers showed that the cysteine proteome of skeletal muscle functioned as a redox buffer in wild-type and murine dystrophin-deficient (mdx) muscle during eccentric contractions, but the buffer capacity in mdx muscle was significantly compromised by elevated basal protein oxidation.
    [Journal of Clinical Investigation]

    AbstractGraphical Abstract

    The Role of MEGF10 in Myoblast Fusion and Hypertrophic Response to Overload of Skeletal Muscle

    To better understand the role of MEGF10 in satellite cells, investigators overexpressed human multiple EGF domain protein 10 (MEGF10) in mouse H-2kb-tsA58 myoblasts and found that it inhibited fusion.
    [Journal of Muscle Research and Cell Motility]

    Full Article

    Inhibition of Aortic CX3CR1+ Macrophages Mitigates Thoracic Aortic Aneurysm Progression in Marfan Syndrome in Mice

    Administering monoclonal antibodies to respectively neutralize TNF-α and IGF1 produced by CX3CR1+ cells from Marfan syndrome (MFS) patients greatly suppressed the cocultured MFS patient-specific induced pluripotent stem cell-derived vascular smooth muscle cell inflammation.
    [Journal of Clinical Investigation]

    Full ArticleGraphical Abstract

    5-Methylcytosine-Modified circRNA-CCNL2 Regulates Vascular Remodeling in Hypoxic Pulmonary Hypertension through Binding to FXR2

    Scientists revealed that hypoxia downregulated circCCNL2 expression, and overexpression of circCCNL2 attenuated pulmonary hypertension progression and inhibited the proliferation of pulmonary artery smooth muscle cell.
    [International Journal of Biological Macromolecules]

    Abstract

    Inflammatory Adhesion Mediates Myocardial Segmental Necroptosis Induced by Mixed Lineage Kinase Domain-Like Protein in Acute Myocardial Infarction

    Researchers explored the effect of endogenous H2S/cystathionine γ-lyase pathway on the endothelin-1/endothelin type A receptor binding and its underlying mechanisms in the cellular and animal models of pulmonary arterial smooth muscle cell proliferation.
    [Cell Communication and Signaling]

    Full Article
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    REVIEWS

    Cardiac Regeneration in Adult Zebrafish: A Review of Signaling and Metabolic Coordination

    The authors investigate how post-injury cellular signaling and energy metabolism are two pivotal points in zebrafish’s cardiomyocyte cell cycle re-entry and proliferation.
    [Current Cardiology Reports]

    Abstract
    INDUSTRY AND POLICY NEWS

    Santhera Receives Positive NICE Final Guidance for AGAMREE® (Vamorolone) as a Treatment for Duchenne Muscular Dystrophy

    Santhera Pharmaceuticals announced that the National Institute for Health and Care Excellence (NICE) has issued positive Final Guidance that recommends AGAMREE® for use in the NHS in England, Wales, and Northern Ireland for the treatment of Duchenne muscular dystrophy in patients 4 years of age and older.
    [Santhera Pharmaceuticals]

    Press Release
    FEATURED EVENT

    5th Growth Factors in Regeneration and Regenerative Medicine Conference

    February 14-17, 2025
    Punta Cana, Dominican Republic

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    JOB OPPORTUNITIES

    Research Assistant – Neuromuscular Electrical Stimulation for Sarcopenia

    University of Leicester – Leicester, England, United Kingdom

    Faculty – Stem Cell and Gene Therapy

    University of California San Francisco – San Francisco, California, United States

    Postdoctoral Fellow – Muscle Biomechanics

    Harvard University – Cambridge, Massachusetts, United States

    Postdoctoral Associate – Human Skeletal Muscle Disease Modeling and Therapy

    Duke University – Durham, North Carolina, United States

    Postdoctoral Fellow – Skeletal Muscle Project

    Harvard University – Cambridge, Massachusetts, United States

    > See All Jobs

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