 | | Vol. 5.27 – 27 July, 2020 |
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| Investigators determined the role of lysosomal-associated transmembrane protein 4B (LAPTM4B) in the regulation of autophagic flux and myocardial ischemia/reperfusion injury.
[Circulation Research] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists describe maturation media designed to provide oxidative substrates adapted to the metabolic needs of human induced pluripotent stem cell-derived cardiomyocytes.
[Cell Reports] |
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| Researchers found that type 2 ryanodine receptor (RYR2)–/–-iPSCs could differentiate into cardiomyocytes (CMs) with the efficiency similar to control-iPSCs; however, the survival of induced pluripotent stem cell-CMs were markedly affected by the lack of functional RYR2.
[Frontiers in Cell and Developmental Biology] |
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| The authors report successful protection from doxorubicin in two independent human pluripotent stem cell-derived cardiomyocyte lines, using two potent, highly selective MAP4K4 inhibitors.
[Scientific Reports] |
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| Scientists found that M2 compared to M1 macrophage-conditioned media upregulated neonatal cardiomyocyte proliferation, suppressed myofibroblast-induced differentiation and stimulated endothelial cell tube formation.
[Scientific Reports] |
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| Investigators demonstrated that striated muscle cells formed a continuous myofibrillar matrix linked together by frequently branching sarcomeres.
[Nature Communications] |
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| Myocardin-related transcription factor A protein expression was inhibited by ectopic miRNA expression in murine C2C12 and primary human myoblasts.
[Nucleic Acids Research] |
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| Investigators showed that knockdown of Drosophila cofilin, an actin depolymerizing factor, disrupted both sarcomere structure and muscle function.
[Cell Reports] |
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| The authors describe the consequences of histone deacetylase 11 (HDAC11) genetic deficiency in skeletal muscle, which resulted in the improvement of muscle function enhancing fatigue resistance and muscle strength.
[FEBS Journal] |
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| In vitro, TWIST1 inhibition or silencing prevented pulmonary artery smooth muscle cell proliferation and migration.
[American Journal of Respiratory and Critical Care Medicine] |
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| Scientists revealed significant response differences between airway smooth muscle cells from asthma cases and controls, including genes implicated in asthma susceptibility.
[Genome Medicine] |
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| The authors present the frontier studies on the roles of ncRNAs in doxorubicin-induced cardiotoxicity, address the possibility and prospects of using ncRNAs as diagnostic biomarkers or therapeutic targets
[Acta Pharmacologica Sinica] |
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| Scientists summarize the updated knowledge, perspectives, and limitations of pluripotent stem cell-derived cardiomyocytes for heart regeneration.
[Journal of Cardiology] |
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| Sarepta Therapeutics, Inc. announced that the FDA has granted Fast Track designation to SRP-9001. SRP-9001 is an investigational gene transfer therapy intended to deliver its micro-dystrophin-encoding gene to muscle tissue for the targeted production of the micro-dystrophin protein.
[Sarepta Therapeutics, Inc.] |
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| The French government this week unveiled a draft science bill that promises to increase public research spending with an extra €25 billion over the next ten years.
[ScienceInsider] |
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| Four Chinese nationals have been charged with visa fraud after revelations that they sent information on the layout of US labs and research carried out by colleagues back to China.
[The Scientist] |
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| August 27 – August 29
Virtual |
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| | UPMC Children’s Hospital of Pittsburgh – Pittsburgh, Pennsylvania, United States |
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| | Duke University – Durham, North Carolina, United States |
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| | Novo Nordisk A/S – Måløv, Denmark |
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| | Spanish National Center for Cardiovascular Research – Madrid, Spain |
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| | Spanish National Center for Cardiovascular Research – Madrid, Spain |
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