Muscle Cell News Volume 9.14 | Apr 22 2024

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    Noshin Noorjahan
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    2024-04-22 | MUSCN 9.14


    Muscle Cell News by STEMCELL Technologies
    Vol. 9.14 – 22 April, 2024
    TOP STORY

    Proximal Telomeric Decompaction Due to Telomere Shortening Drives FOXC1-Dependent Myocardial Senescence

    Investigators demonstrated that in heart failure patient cardiomyocytes, telomeres were shortened compared to healthy controls.
    [Nucleic Acids Research]

    AbstractGraphical Abstract
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    PUBLICATIONSRanked by the impact factor of the journal

    HOIL-1L Deficiency Induces Cell Cycle Alteration Which Causes Immaturity of Skeletal Muscle and Cardiomyocytes

    The authors elucidated the mechanisms by which myopathy and dilated cardiomyopathy develop using the murine myoblast cell line C2C12 and disease-specific human induced pluripotent stem cells.
    [Scientific Reports]

    Full Article

    Human Skeletal Muscle Aging Atlas

    Researchers profiled 90,902 single cells and 92,259 single nuclei from 17 donors to map the aging process in the adult human intercostal muscle, identifying cellular changes in each muscle compartment.
    [Nature Aging]

    Full Article

    Arginine Ingestion Inhibits Phagocyte Invasion in Eccentrically Contracted Rat Fast-Twitch Muscle

    Scientists investigated whether prior ingestion of L-arginine, a nitric oxide precursor, inhibited eccentric contraction-induced macrophage invasion.
    [Journal of Muscle Research and Cell Motility]

    Full Article

    KLF13 Promotes VSMCs Phenotypic Dedifferentiation by Directly Binding to the SM22α Promoter

    The authors investigated the relationship between KLF13 and SM22α expression in normal and atherosclerotic plaques by bioanalysis, and observed a significant increase in KLF13 levels in the atherosclerotic plaques of both human patients and ApoE−/− mice.
    [Journal of Cellular Physiology]

    Abstract

    LncRNA MIR210HG Promotes Phenotype Switching of Pulmonary Arterial Smooth Muscle Cells through Autophagy-Dependent Ferroptosis Pathway

    Investigators identified for the first time the potential effect of MIR210HG on disease progression in hypoxic pulmonary hypertension.
    [Apoptosis]

    Abstract
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    REVIEWS

    Progress of Mitochondrial Function Regulation in Cardiac Regeneration

    The authors review mitochondria’s multifaceted role in cardiac regeneration, particularly in myocardial infarction and heart failure models.
    [Journal Of Cardiovascular Translational Research]

    AbstractGraphical Abstract
    INDUSTRY AND POLICY NEWS

    Canadian Science Gets Biggest Boost to PhD and Postdoc Pay in 20 Years

    Researchers in Canada got most of what they were hoping for in the country’s 2024 federal budget, with a big boost in postgraduate pay and more funding for research and scientific infrastructure.
    [Nature]

    Editorial
    FEATURED EVENT

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    JOB OPPORTUNITIES

    Scientist – Cardiovascular Pathophysiology and Vascular Cell Biology

    University of Florida – West Palm Beach, Florida, United States

    Postdoctoral Associate – Muscle Study

    Baylor College of Medicine – Houston, Texas, United States

    Research Assistant – Cancer Study

    Singapore Institute Of Technology – Singapore, Singapore

    Postdoctoral Positions – Biotechnology

    Sapienza University – Rome, Italy

    Postdoctoral Research Associate – Molecular Biology, Cell Biology, & Biochemistry

    Brown University – Providence, Rhode Island, United States

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