Muscle Cell News Volume 9.23 | Jul 8 2024

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    Noshin Noorjahan
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    2024-07-08 | MUSCN 9.23


    Muscle Cell News by STEMCELL Technologies
    Vol. 9.23 – 8 July, 2024
    TOP STORY

    Therapeutic Efficacy of Mexiletine for Long QT Syndrome Type 2: Evidence From Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes, Transgenic Rabbits, and Patients

    Heart rate–corrected field potential duration, a surrogate for QTc, was measured in human induced pluripotent stem cells from two patients with long QT syndrome type 2 before and after mexiletine using a multiwell multi-electrode array system.
    [Circulation]

    Abstract
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    Cardiomyocyte PANX1 Controls Glycolysis and Neutrophil Recruitment in Hypertrophy

    Researchers generated a novel mouse line with constitutive deletion of PANX1 in cardiomyocytes. PANX1 deletion in cardiomyocytes had no effect on unstressed heart function but increased the glycolytic metabolism and resulting glycolytic ATP production.
    [Circulation Research]

    AbstractGraphical Abstract

    FOXO-Regulated DEAF1 Controls Muscle Regeneration through Autophagy

    Investigators identified a new regulator of muscle regeneration, deformed epidermal autoregulatory factor-1 (Deaf1) – a transcriptional factor downstream of forkhead box O (foxo) signaling.
    [Autophagy]

    Full Article

    Aerobic Exercise Suppresses CCN2 Secretion from Senescent Muscle Stem Cells and Boosts Muscle Regeneration in Aged Mice

    Mice underwent moderate-intensity continuous training from nine months0 or 20 months to 25 months, with age-matched and adult controls. Histological examinations and muscle stem cell (MuSC) transplantation assays assessed aerobic exercise effects on MuSC function and muscle regeneration.
    [Journal of Cachexia Sarcopenia and Muscle]

    Full Article

    EDIL3/Del-1 Prevents Aortic Dissection through Enhancing Internalization and Degradation of Apoptotic Vascular Smooth Muscle Cells

    Scientists investigated whether EDIL3 promoted the internalization and degradation of apoptotic vascular smooth muscle cells during thoracic aortic dissection.
    [Autophagy]

    Abstract

    Loss of Smooth Muscle Tenascin-X Inhibits Vascular Remodeling through Increased TGF-β Signaling

    The authors studied the role of tenascin-X in vascular smooth muscle cells (VSMCs) in various murine disease models using tamoxifen-inducible SMC-specific knockout and adeno-associated virus–mediated knockdown.
    [Arteriosclerosis Thrombosis and Vascular Biology]

    Abstract
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    REVIEWS

    Epigenetic Control of Skeletal Muscle Atrophy

    Scientists discuss how epigenetic modifications change during the process of skeletal muscle atrophy, the molecular mechanisms by which epigenetic regulatory proteins control skeletal muscle atrophy, and assess their translational potential.
    [Cellular & Molecular Biology Letters]

    Full Article

    Mitochondrial Adaptation in Skeletal Muscle: Impact of Obesity, Caloric Restriction, and Dietary Compounds

    Investigators summarize recent findings on the impact of obesity on skeletal muscle mitochondria structure and function, the molecular mechanism of mitochondrial quality control systems, and how obesity impacts these systems.
    [Current Nutrition Reports]

    Full Article
    INDUSTRY AND POLICY NEWS

    Preliminary Drug Trial Results Give Hope to Those with a Common Form of Muscular Dystrophy

    An experimental drug designed to treat one of the most common forms of muscular dystrophy successfully reduced levels of a rogue protein that causes the disease, according to preliminary results of a multi-site clinical trial that includes the University of Kansas Medical Center.
    [University of Kansas Medical Center]

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