Neural Cell News Volume 10.28 | Jul 20 2016

TOP STORY

Comprehensive Map of Primate Brain Development Published in Nature

Researchers have published an in-depth analysis of a comprehensive molecular atlas of brain development in the non-human primate. This analysis uncovers features of the genetic code underlying brain development in our close evolutionary relative, while revealing distinct features of human brain development by comparison. [Press release from The Allen Institute of Brain Science discussing online prepublication in Nature] Press Release | Abstract

(Ranked by impact factor of the journal)

Return to Quiescence of Mouse Neural Stem Cells by Degradation of a Proactivation Protein

Scientists found that the E3-ubiquitin ligase Huwe1 (HECT, UBA, and WWE domain–containing 1) is required for proliferating stem cells of the adult mouse hippocampus to return to quiescence. [Science] Abstract | Press Release

Neuronal Activity Enhances Tau Propagation and Tau Pathology In Vivo

Investigators showed that physiological tau released from donor cells can transfer to recipient cells via the medium, suggesting that at least one mechanism by which tau can transfer is via the extracellular space. [Nat Neurosci] Abstract | Press Release

ALS Disrupts Spinal Motor Neuron Maturation and Aging Pathways within Gene Co-Expression Networks

Scientists compared transcriptomes among induced pluripotent stem cells-derived spinal motor neurons, fetal spinal tissues and adult spinal tissues. [Nat Neurosci] Abstract | Press Release

Reprogramming Müller Glia via In Vivo Cell Fusion Regenerates Murine Photoreceptors

Scientists demonstrated that retinal Müller glia can be reprogrammed in vivo into retinal precursors that then differentiate into photoreceptors. [J Clin Invest] Full Article

Optimal Myelin Elongation Relies on YAP Activation by Axonal Growth and Inhibition by Crb3/Hippo Pathway

Investigators showed that peripheral myelin elongation is dynamically regulated by stimulation of yes-associated protein (YAP) transcription cofactor activity during axonal elongation and limited by inhibition of YAP activity via the Hippo pathway. [Nat Commun] Full Article

Iterative Role of Notch Signaling in Spinal Motor Neuron Diversification

Using an in vitro neural differentiation model, researchers demonstrated that motor neuron progenitor differentiation is iteratively controlled by Notch signaling. [Cell Rep] Full Article

Neurons Differentiated from Transplanted Stem Cells Respond Functionally to Acoustic Stimuli in the Awake Monkey Brain

Researchers examined whether neurons differentiated from transplanted stem cells can integrate into the host neural network and function in awake animals, a goal of transplanted stem cell therapy in the brain. [Cell Rep] Full Article

Intermittent High Oxygen Influences the Formation of Neural Retinal Tissue from Human Embryonic Stem Cells

Using three-dimensional culture of human stem cells, scientists examined the effect of intermittent high oxygen treatment on the formation and cellular behavior of neural retinas in the embryonic body. [Sci Rep] Full Article

Reciprocal Regulation between Bifunctional miR-9/9(*) and its Transcriptional Modulator Notch in Human Neural Stem Cell Self-Renewal and Differentiation

Scientists found that miR-9/9(*) decreases Notch activity by targeting NOTCH2 and HES1, resulting in an enhanced differentiation. Vice versa, expression levels of miR-9/9(*) depend on the activation status of Notch signaling. [Stem Cell Reports] Full Article | Graphical Abstract

By Changing Dimensionality, Sequential Culturing of Midbrain Cells, Rather than Two-Dimensional Culture, Generates a Neuron-Glia Ratio Closer to In Vivo Adult Midbrain

Researchers aimed to develop an in vitro midbrain culture which would replicate a similar neuron-glia ratio to that in in vivo adult midbrain while containing a similar number of dopaminergic neurons. [Cells Tissues Organs] Abstract

The Bowel and Beyond: The Enteric Nervous System in Neurological Disorders

The authors reviewed evidence for enteric nervous system (ENS) dysfunction in the aetiopathogenesis of autism spectrum disorder, amyotrophic lateral sclerosis, transmissible spongiform encephalopathies, Parkinson disease and Alzheimer disease. [Nat Rev Gastroenterol Hepatol] Abstract

Visit our reviews page to see a complete list of reviews in the neural cell research field.

Allen Brain Observatory Launched

The Allen Institute for Brain Science announced the release of the Allen Brain Observatory: a highly standardized survey of cellular-level activity in the mouse visual system. [Allen Institute of Brain Science] Press Release

Columbia University Awarded $58.4 Million to Accelerate Development of New Therapies

Columbia University Medical Center has received a $58.4 million grant from the National Center for Advancing Translational Sciences at the National Institutes of Health to expand its work in translational research. [Columbia University] Press Release

Dutch Agency Launches First Grants Program Dedicated to Replication

The Netherlands has launched what researchers say is the world’s first national fund dedicated to replication studies: a pot of €3 million over the next 3 years for Dutch scientists to test whether they can reproduce important research results in social and medical sciences. [Nature News] Editorial

First Greek Science Agency Is Rare Source of Joy for Beleaguered Researchers

A massive loan from the European Union’s investment bank gives Greek researchers their first ray of hope since the debt crisis hit six years ago: a government-backed plan to create a Greek research agency. [Nature News] Editorial

NEW European CNS Summit 2016
September 12-14, 2016
London, United Kingdom

Visit our events page to see a complete list of events in the neural cell community.

NEW Senior Scientist – Neurology (Korea Brain Research Institute)

NEW Postdoctoral Researcher – Neuroscience (Max Planck Society)

NEW Postdoctoral Research Fellows – Australian Institute for Bioengineering and Nanotechnology (The University of Queensland)

Assistant Professor – Neuroimaging and Informatics (University of Southern California)

Researcher – Neuroanatomy, Neuroinformatics and Brain Atlasing (University of Oslo)

Director of the NIH Brain Initiative (National Institute of Neurological Disorders and Stroke National Institutes of Health)

Postdoctoral Fellow – Neural Stem Cell/Gene Therapy Research (Thomas Jefferson University)

Postdoctoral Position – Brain Injury and Repair (University of Pennsylvania)

Postdoctoral Fellow Positions – Pharmacology (The University of Tennessee Health Science Center)

Postdoctoral Positions – Cell Biology (Boston University)

Postdoctoral Position – Neuroscience (Inserm-ENS)

Faculty Positions – Brain Research (IDG/McGovern Institute for Brain Research at Peking University)

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