 | | Vol. 14.40 – 21 October, 2020 |
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| Using a model of chronic hypoxia-inducible factor 1a (HIF1a) accumulation in pluripotent-stem-cell-derived oligodendrocyte progenitors (OPCs), researchers demonstrated that HIF1a activates non-canonical targets to impair generation of oligodendrocytes from OPCs.
[Cell Stem Cell] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that H3K79me2 increases and H3K27ac decreases globally during in vitro neuronal differentiation of murine embryonic stem cells.
[Nature Communications] |
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| Scientists determined that the Siah2 E3 ubiquitin ligase functions in a coincidence detection circuit linking responses to the Shh mitogen and the extracellular matrix to control cerebellar granule neurons germinal zone occupancy.
[Nature Communications] |
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| Investigators showed that G3BP1 phosphorylation by casein kinase 2α (CK2α) triggered G3BP1 granule disassembly in injured axons. CK2α activity was temporally and spatially regulated by local translation of Csnk2a1 mRNA in axons after injury, but this required local translation of mTor mRNA and buffering of the elevated axonal Ca2+ that occurred after axotomy.
[Current Biology] |
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| Researchers found that knockdown of cap methyltransferase 1 (CMTR1) impaired dendrite development independent of secretory cytokines and retinoic-acid-inducible gene-I (RIG-I) signaling.
[Cell Reports] |
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| The authors used an adapted cell preparation of isolated postnatal neural stem cells (NSCs) and live imaging to demonstrate that cerebellar progenitors maintain their neurogenic nature by displaying hallmarks of NSCs.
[Stem Cell Reports] |
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| Short‐term cultures of glioma neural stem cells were compared to cultures of healthy astrocytes and neurons using flow cytometry. Glioblastoma tissues were dissociated and analyzed by high‐parameter flow cytometry and single‐cell transcriptomics.
[Clinical & Translational Immunology] |
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| Scientists showed that Sorcin expression levels were strongly increased in cellular, animal, and human models of Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease, vs. normal cells.
[Cell Death & Disease] |
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| Researchers found that Dynamin-related protein 1 was dephosphorylated in several ALS models, including those with SOD1 and TDP-43 mutations, and the dephosphorylation was mediated by the pathological induction of protein phosphatase 1 activity in these models.
[Cell Death & Disease] |
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| Investigators tested the capacity of a carbon material composed of amorphous sp3 carbon backbone, embedded with a percolating network of sp2 carbon domains to sustain neuronal cultures. They found that cortical neurons survived and developed faster on this novel carbon material.
[Scientific Reports] |
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| Researchers explored the underlying mechanisms behind treatment resistance and the lack of success with anti-EGFR therapy in the clinic. After generating a number of treatment-resistant Glioblastoma cell lines, they observed that resistant cell lines lacked EGFR activation and expression.
[Scientific Reports] |
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| Scientists used oxygen-glucose deprivation/reoxygenation-induced injury in neuronal cells and middle cerebral artery occlusion-induced brain ischemia/reperfusion injury in rats to mimic ischemic brain injury, and hypothesized that the CB1 receptor agonist arachidonyl-2-chloroethylamide (ACEA) would protect ischemic neurons by inhibiting mitochondrial fission via dynamin-related protein 1 (Drp1).
[Cell Death Discovery] |
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| The early-generated, largely transient neurons of the subplate play a key role in integrating spontaneous and sensory-driven activity. Early pathological conditions — such as hypoxia, inflammation, or exposure to pharmacological compounds — alter spontaneous activity patterns, which subsequently induce disturbances in cortical network activity.
[Science] |
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| A highly pleiotropic and context-dependent nature of protein interacting with NIMA-1 (Pin1) functional activity, strictly dependent on the phosphorylation patterns of its cellular targets, clearly emerges. In the nervous system, Pin1 is fundamental both for embryonic development and cellular homeostasis in adult neurons, due to its role as regulator of cell death and survival.
[Molecular Neurobiology] |
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| Cyclo Therapeutics, Inc. received notification from the US FDA that enrollment could proceed for its Phase III global pivotal clinical trial.
[Cyclo Therapeutics, Inc.] |
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| NOXXON Pharma N.V. announced the collaboration with three additional clinical sites to increase recruitment capacity for the Phase I/II brain cancer study of NOX-A12 plus radiotherapy, as a measure to ensure the timely completion of the study under the current challenging conditions posed by the COVID-19 pandemic.
[NOXXON Pharma N.V.] |
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| November 11 – November 13
Virtual |
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| | Vanderbilt University – Nashville, Tennessee, United States |
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| | F. Hoffmann-La Roche AG – Basel, Switzerland |
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| | University of Copenhagen – Copenhagen, Denmark |
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| | Edward Via College of Osteopathic Medicine – Spartanburg, South Carolina, United States |
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| | Boston University – Boston, Massachusetts, United States |
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