 | | Vol. 15.38 – 29 September, 2021 |
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| Scientists investigated the neuronal reprogramming capacity of CEND1 and/or Neurogenin-2 (NEUROG2) upon their overexpression on primary human adult cortical astrocytes.
[International Journal of Developmental Biology] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Using stringent lineage tracing in the mouse brain, investigators showed that the presumed astrocyte-converted neurons were actually endogenous neurons.
[Cell] |
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| Researchers demonstrated that glutamate receptors of the kainate receptor subfamily were expressed in adult-born dentate granule cells and that, through their interaction with GABAergic signaling mechanisms, they altered the functional properties of adult-born cells during a critical period of their development.
[Cell Reports] |
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| The authors showed that secreted frizzled-related protein 1 (SFRP1), a multifunctional regulator of cell-to-cell communication, was part of the cellular crosstalk underlying neuroinflammation.
[EMBO Reports] |
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| Scientists identified HOTAIRM1 as a candidate long non-coding RNA whose up-regulation was significantly associated with shorter survival of glioblastoma patients, independent from isocitrate dehydrogenase mutation and O6-methylguanine DNA methyltransferase promoter methylation.
[Cell Death & Disease] |
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| Isolated cells retain key in vivo self-renewal properties and their cell-type profile reflects the cell composition of their source area, while the function of the niche is sustained even eight months post-milking.
[Stem Cell Reports] |
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| Researchers presented human patient induced pluripotent stem cell-derived neurons cultured on densely-spaced spiky silicon nanowire arrays which showed mature electrophysiological characteristics after only 20 days of culturing.
[Scientific Reports] |
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| POU2F1/Oct-1 is a transcription regulator in higher eukaryotes which is involved in the regulation of development, differentiation, stress response, and other processes. Increased Oct-1Z expression levels in differentiating human neuroblasts activated genes controlling stress response, neural cell differentiation, brain formation, and organogenesis.
[Scientific Reports] |
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| As the tumor microenvironment is typically acidic due to increased glycolysis and consequently leads to an increased production of lactic acid in tumor cells, the role of acid‑sensing ion channel 1a (ASIC1a), an acid sensor, was explored as a tumor suppressor in gliomagenesis and stemness.
[International Journal of Oncology] |
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| Investigators discuss the immune modulatory functions of microglia, monocyte-derived macrophages and astrocytes in brain metastases and glioma.
[Nature Reviews Cancer] |
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| The authors review the development, distribution, neurochemical phenotypes, and possible functions of pericellular baskets. They highlight pericellular baskets formed by projections of certain Pet1/Fev neurons of the serotonergic raphe nuclei.
[Trends in Neurosciences] |
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| GeneTx Biotherapeutics LLC and Ultragenyx Pharmaceutical Inc. announced that the FDA has removed the clinical hold and GeneTx may begin dosing naïve patients in the Phase I/II study of GTX-102 in pediatric patients with Angelman syndrome.
[GeneTx Biotherapeutics LLC] |
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| Brain and stem cell researchers from The University of Texas at San Antonio have secured $12.5 million in funding over five years from the National Institutes of Health through the NIH BRAIN Initiative to advance new methods for studying genetic brain disorders.
[The University of Texas at San Antonio] |
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| October 19 – 20, 2021
Virtual |
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| | Brigham and Women’s Hospital – Boston, Massachusetts, United States |
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| | University of Helsinki – Helsinki, Finland |
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| University of Southern California – Los Angeles, California, United States |
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| Emory University – Atlanta, Georgia, United States |
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| University of Maryland, College Park – College Park, Maryland, United States |
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