 | | Vol. 18.40 – 16 October, 2024 |
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| Researchers explored the utility and accuracy of noninvasive plasma biomarkers for early brain metastasis (BM) identification. They showed that plasma cell-free circulating tumor DNA methylomes could noninvasively differentiate BM from other main differential diagnoses via peripheral blood sampling.
[Nature Medicine] |
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| PUBLICATIONSListed by the impact factor of the journal |
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| Scientists found that induced pluripotent stem cell-derived human dopaminergic neurons form lewy body-like inclusions after treatment with α-synuclein preformed fibrils but only when coupled to a model of immune challenge or when co-cultured with activated microglia-like cells.
[Nature Neuroscience] |
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| The authors used multiomics, spatial genomics, and reference atlases from the BRAIN Initiative to study middle temporal gyrus cell types in 84 donors with varying Alzheimer’s disease pathologies.
[Nature Neuroscience] |
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| Researchers studied SLIT-ROBO Rho GTPase Activating Protein 2 (SRGAP2) B/C, two human-specific gene duplications of the ancestral synaptic gene SRGAP2A, in human cortical pyramidal neurons xenotransplanted in the mouse cortex, which led to strongly accelerated synaptic development.
[Neuron] |
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| The authors developed a multiplex in vivo perturb-seq CRISPRi platform for single-cell genetic screens in cancer and tumor microenvironment cells that leveraged intracranial convection enhanced delivery of sgRNA libraries into mouse models of glioblastoma.
[Genome Biology] |
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| Investigators applied a novel computational workflow to a spatiotemporally profiled glioblastoma xenograft cohort, leveraging the ability to distinguish human tumor from mouse tumor microenvironment to overcome previous limitations in the analysis of diffuse invasion.
[Genome Biology] |
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| To evaluate how modulation of SUMOylation might influence functional measures of neuronal activity in Huntington’s disease cells in vitro, scientists utilized primary neuronal cultures from R6/2 transgenic and non-transgenic mice.
[Brain] |
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| Researchers characterized the transcriptional diversity of distinct NEUN+ populations in the human ventral midbrain and then tested for schizophrenia-associated changes in neuronal subset proportions and gene activity changes within neuronal subsets.
[Brain] |
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| Investigators fabricated sub-10nm multifunctional dual-carbon dots composites (ERCD) with photo-propelled nanomotor behavior. Near-infrared-activated ERCD-1 imaged Aβ plaques in vivo and prolonged nematode lifespan by six sdays at 2 µg mL-1.
[Small] |
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| The authors fabricated a novel elastic bovine serum albumin hydrogel, which was used to deliver paclitaxel together with basic fibroblast growth factor to inhibit glial scar formation as well as promote axon regeneration and motor function for spinal cord injury repair.
[Small] |
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| Scientists examined the effects of electroconvulsive therapy on blood-based biomarkers of neuronal injury and astrocytic reactivity.
[Molecular Psychiatry] |
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| With all the remarkable new approaches to treat neurological disorders, the authors take a critical look at the state of current clinical trials and how challenges may be overcome with the evolving technology and innovation occurring in the stem cell field.
[Nature Medicine] |
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| Recent technical advances, such as single-cell omics and the development of induced pluripotent stem cell models of Down syndrome (DS), now enable in-depth analyses of the biochemical and molecular drivers of altered brain development in DS.
[Nature Reviews Neuroscience] |
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| Scientists explore the therapeutic potential of glia in transplantation with an emphasis on novel bioengineered tools for enhancement of their reparative properties.
[Acta Biomaterialia] |
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| Dr. Vidhya Rangaraju, research group leader at the Max Planck Florida Institute for Neuroscience (MPFI) has been awarded the prestigious NIH Director’s New Innovator Award for her research on how the brain generates and regulates energy.
[MPFI] |
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| Allyx Therapeutics announced that it has been awarded a $3.3 million grant from the National Institutes of Health. This funding will support further investigation of Allyx’s lead clinical asset, ALX-001, a highly-selective oral therapy in development for the treatment of Alzheimer’s disease and Parkinson’s disease.
[Allyx Therapeutics (GlobeNewswire)] |
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| Emory University researchers from Dr. Thota Ganesh’s lab are looking at inflammation in the brain – also known as neuroinflammation – and how it contributes to cognitive decline.
[Emory University] |
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| November 17-20, 2024
Bellevue, Washington, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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| | University of Michigan – Ann Arbor, Michigan, United States |
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| | Wellcome Trust – Cambridge, England, United Kingdom |
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| | Colorado State University – Fort Collins, Colorado, United States |
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| | St. Jude Children’s Research Hospital – Memphis, Tennessee, United States |
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