Organoid News Volume 2.44 | Dec 2 2021

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    2021-12-02 | ON 2.44


    Organoid News by STEMCELL Technologies
    Vol. 2.44 – 2 December, 2021
    TOP STORY

    Microbial Regulation of Hexokinase 2 Links Mitochondrial Metabolism and Cell Death in Colitis

    Scientists examined the microbial regulation of hexokinase 2 and its impact on inflammation using mice lacking hexokinase 2 in intestinal epithelial cells.
    [Cell Metabolism]

    AbstractGraphical Abstract
    Virtual Conference Exhibition: Pluripotent Stem Cells
    PUBLICATIONSRanked by the impact factor of the journal

    Functional Human Gastrointestinal Organoids Can Be Engineered from Three Primary Germ Layers Derived Separately from Pluripotent Stem Cells

    Researchers developed an organoid assembly approach starting with cells from the three primary germ layers—enteric neuroglial, mesenchymal, and epithelial precursors—that were derived separately from human PSCs.
    [Cell Stem Cell]

    AbstractGraphical Abstract

    Genome-Wide Screening in Human Kidney Organoids Identifies Developmental and Disease-Related Aspects of Nephrogenesis

    A functional dataset allowed improving mesoderm induction by ROCK inhibition, contained monogenetic and complex trait kidney disease genes, confirmed two additional congenital anomalies of the kidney and urinary tract genes, and provided a large candidate list of ciliopathy-related genes.
    [Cell Stem Cell]

    AbstractGraphical Abstract

    Lymphangion-Chip: A Microphysiological System Which Supports Co-Culture and Bidirectional Signaling of Lymphatic Endothelial and Muscle Cells

    A fabrication technique was developed to create a lymphangion-chip. This organ-on-chip consisted of co-culture of a monolayer of endothelial lumen surrounded by multiple and uniformly thick layers of muscle cells.
    [Lab On A Chip]

    AbstractGraphical Abstract

    Microfluidic Organ-on-Chip System for Multi-Analyte Monitoring of Metabolites in 3D Cell Cultures

    Investigators developed a microfluidic organ-on-chip platform for matrix-based, heterogeneous 3D cultures with fully integrated electrochemical chemo- and biosensor arrays for the energy metabolites oxygen, lactate, and glucose.
    [Lab On A Chip]

    Full ArticleGraphical Abstract

    Patient-Derived Organoids as a Preclinical Platform for Precision Medicine in Colorectal Cancer

    The authors investigated whether drug responses of organoids correlated with clinical responses of matched patients and disease progression of patients.
    [Molecular Oncology]

    AbstractFull Article

    The Sodium/Glucose Cotransporters as Potential Therapeutic Targets for Cystic Fibrosis Lung Diseases Revealed by Human Lung Organoid Swelling Assay

    Investigators derived human proximal lung organoids from patient-derived PSCs carrying disease-causing cystic fibrosis transmembrane conductance regulator mutations.
    [Molecular Therapy-Methods & Clinical Development]

    AbstractFull ArticleGraphical Abstract

    Mouse Lung Organoid Responses to Reduced, Increased, and Cyclic Stretch

    To address limitations in cell culture and in vivo mechanotransductive models, scientists developed two mouse lung organoid mechanotransductive models using postnatal day five mouse lung CD326-positive cells and fibroblasts subjected to increased, decreased, and cyclic strain.
    [American Journal of Physiology-Lung Cellular and Molecular Physiology]

    Abstract

    SIRT1 Induces the Accumulation of TAMs at Colorectal Cancer Tumor Sites via the CXCR4/CXCL12 Axis

    Researchers examined tumor-infiltrating lymphocytes in colorectal cancer expressing different levels of SIRT1 and established a co-culture system with monocytes, CD8+ T cells and patient-derived tumor organoids to study the relationships between immune cells and cancer cells.
    [Cellular Immunology]

    Abstract

    A Labroots 2021 Webinar: iPSCs As Models, Part 2: Modeling the Human Brain with Organoids, presented by Dr. Anjana Nityanandam, Director of the Human Stem Cell Lab core facility at St. Jude Children’s Research Hospital. Click to Watch Now.
    REVIEWS

    Human Meibomian Gland Epithelial Cell Culture Models: Current Progress, Challenges, and Future Directions

    In serum-free medium, rosiglitazone, a peroxisome proliferator activator receptor-γ agonist, was reported to induce immortalised human meibomian gland epithelia cell differentiation, neutral lipid accumulation and expression of key biomarkers of differentiation.
    [Ocular Surface]

    Abstract

    Harnessing Cerebral Organoids for Alzheimer’s Disease Research

    Scientists review the most recent advances in modeling Alzheimer’s disease in organoids and other engineered 3D cell culture systems.
    [Current Opinion in Neurobiology]

    Abstract
    INDUSTRY AND POLICY NEWS

    Chinook Therapeutics Announces Formation of SanReno Therapeutics, a Joint Venture to Develop Kidney Disease Therapies in China

    Chinook Therapeutics, Inc. announced the formation of SanReno Therapeutics, a joint venture with an investor syndicate led by Frazier Healthcare Partners and Pivotal bioVenture Partners China, to develop, manufacture and commercialize kidney disease therapies.
    [Chinook Therapeutics, Inc.]

    Press Release

    Mount Sinai Researchers Awarded $3.15 Million to Advance a Multidisciplinary Drug Development Platform for Hepatocellular Carcinoma

    The National Cancer Institute has awarded Mount Sinai researchers $3.15 million in grant funding to assess the potential of a multidisciplinary drug development platform to identify new biological targets for precision-based therapeutics for hepatocellular carcinoma.
    [Mount SInai]

    Press Release
    FEATURED EVENT

    Immunometabolism at the Crossroads of Obesity and Cancer

    January 16 – 20, 2022
    Banff, Alberta, Canada

    > See All Events

    JOB OPPORTUNITIES

    Postdoctoral Fellowship – Bioengineering Neural Morphogenesis

    KU Leuven – Leuven, Belgium

    Researcher – Cell Biologist

    Accession Therapeutics – Oxford, England, United Kingdom

    Research Scientists – Stem Cells and Organoids

    RIKEN – Hirosawam, Japan

    Postdoctoral Fellow – Cell Biology of Metabolic Regulation

    Harvard Joslin Diabetes Center – Boston, Massachusetts, United States

    Postdoctoral Fellow – Cell Biology And Genomics Of Liver Injury

    Emory University – Atlanta, Georgia, United States

    > See All Jobs

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