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| Scientists established a simple 3D culture system that allowed for the generation and manipulation of neuroepithelia organoids from hiPSCs, displaying developmental phases of hiPSC differentiation and self-aggregation.
[Advanced Science] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers showed that the matricellular protein cellular communication network factor 1 (CCN1)/CYR61 coordinately regulated intestinal stem cells proliferation and differentiation through distinct pathways emanating from CCN1 interaction with integrins αvβ3/αvβ5.
[Nature Communications] |
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| The authors used high-throughput, image-based profiling to quantify phenotypes of over 5 million individual colorectal cancer organoids after treatment with >500 small molecules.
[Nature Communications] |
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| In prostate cancer cell lines and organoids, PIK3R1 loss/mutation was associated with increased sensitivity to AKT inhibitors.
[Clinical Cancer Research] |
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| Functional experiments using organoid models, explant cultures, and FACS-isolated R-SPONDIN2+ (RSPO2+) mesenchyme showed that RSPO2 was a critical niche cue that potentiated WNT signaling in bud tip progenitors to support their maintenance and multipotency.
[Developmental Cell] |
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| Investigators found that heat shock transcription factor 1 (HSF1) accumulated in the mitochondria of Huntington’s disease (HD) cell models, a YAC128 mouse model, and human striatal organoids derived from HD iPSCs.
[EMBO Molecular Medicine] |
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| Using organoid culture and xenograft models, researchers demonstrated the highly selective use of birinapant based combinations for the treatment of RB-deficient tumors.
[Oncogene] |
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| Scientists showed that loss of the tumor suppressor adenomatous polyposis coli, which constituted the initiating event in the adenoma-carcinoma sequence for colorectal cancer, induced expression of RNA polymerase I transcription machinery and subsequently upregulated ribosomal DNA transcription.
[Molecular Oncology] |
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| A small-molecule RNF31 inhibitor sensitized colon carcinoma organoids to tumor necrosis factor and greatly enhanced bystander killing of MHC antigen-deficient tumor cells.
[Cell Reports Medicine] |
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| The authors review different factors of the tumor microenvironment (TME) that recent microfluidic in vitro systems reproduce to generate advanced tools to imitate the crosstalk between the TME and the immune system.
[Advanced Drug Delivery Reviews] |
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| Recent advances in iPSC technology have made it possible to generate patient-derived dopaminergic neuronal cell culture and organoid models of Parkinson’s disease.
[Trends in Neurosciences] |
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| Scientists discuss how organ-on-a-chip has contributed to the understanding of human lung structure-function relationships at the cell, tissue, and organ levels.
[Physiology] |
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| Altos Labs announced that it has signed a sponsored research agreement with the Center for iPS Cell Research and Application (CiRA) at Japan’s Kyoto University.
[Altos Labs (Cision US, Inc.)] |
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| September 19 – 20, 2022
Vejle, Denmark |
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| | Francis Crick Institute – London, England, United Kingdom |
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| | Temple University – Philadelphia, Pennsylvania, United States |
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| | Electrophysiology and Heart Modeling Institute – Bordeaux, France |
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| | University Medical Center Utrecht – Utrecht, Netherlands |
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| | Stem Cell Network – Ottawa, Ontario, Canada |
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