Organoid News Volume 4.23 | Jun 15 2023

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    2023-06-15 | ON 4.23


    Organoid News by STEMCELL Technologies
    Vol. 4.23 – 15 June, 2023
    TOP STORY

    Directed Differentiation of Mouse Pluripotent Stem Cells into Functional Lung-Specific Mesenchyme

    Researchers generated a mouse iPSC line carrying a lung-specific mesenchymal reporter/lineage tracer and identified the pathways necessary to specify lung mesenchyme.
    [Nature Communications]

    Full ArticlePress Release
    Grow Functional Airway Organoids with PneumaCultâ„¢
    PUBLICATIONSRanked by the impact factor of the journal

    Graphene Hybrid Inner Ear Organoid with Enhanced Maturity

    Investigators proposed the use of nanomaterial-based approaches, specifically by using graphene oxide to overcome the limitations in generating inner ear organoids.
    [Nano Letters]

    AbstractGraphical Abstract

    3D Bioprinted Vascularized Lung Cancer Organoid Models with Underlying Disease Capable of More Precise Drug Evaluation

    An advanced vascularized lung cancer (LC) model was proposed, which included patient-derived LC organoids, lung fibroblasts, and perfusable vessels using 3D bioprinting technology.
    [Biofabrication]

    Abstract

    Nanoblades Allow High-Level Genome Editing in Murine and Human Organoids

    The authors described the use of the ‘nanoblade’ technology, which outperformed by far gene editing levels achieved to date for murine and human tissue-derived organoids.
    [Molecular Therapy – Nucleic Acids]

    AbstractFull ArticleGraphical Abstract

    Patient Induced Pluripotent Stem Cell-Derived Hepatostellate Organoids Establish a Basis for Liver Pathologies in Telomeropathies

    Researchers used isogenic hiPSCs harboring a causal dyskeratosis congenita (DC) mutation in DKC1, or a CRISPR-Cas9-corrected control allele to model DC liver pathologies.
    [Cellular and Molecular Gastroenterology and Hepatology]

    AbstractFull Article

    Generation and Purification of ACTH-Secreting hPSC-Derived Pituitary Cells for Effective Transplantation

    Building on development of self-organizing culture to generate pituitary-hypothalamic organoids (PHOs) using human pluripotent stem cells (hPSCs), the authors established techniques to generate PHOs using feeder-free hPSCs and to purify pituitary cells.
    [Stem Cell Reports]

    Full ArticleGraphical Abstract

    Characterization of an Eye Field-Like State during Optic Vesicle Organoid Development

    Using optic vesicle organoids to model the onset of the eye field, scientists generated timecourse transcriptomic data allowing them to identify dynamic gene expression programs that characterized this cellular-state transition.
    [Development]

    Abstract

    MeCP2 Dysfunction Prevents Proper BMP Signaling and Neural Progenitor Expansion in Brain Organoid

    Investigators newly established the Rett syndrome brain organoid model derived from methyl-CpG binding protein 2 (MeCP2)-truncated iPSCs which were genetically engineered by CRISPR/Cas9 technology.
    [Annals Of Clinical And Translational Neurology]

    Full Article

    Three-Dimensional Modeling of Solid Tumors and Their Microenvironment to Evaluate T Cell Therapy Efficacy In Vitro

    Researchers investigated the cellular anti-tumor reactivity of αβ T cells engineered to express a defined γδ TCR and developed a 3D cytotoxicity assay targeting cell line–derived spheroids.
    [Journal Of Immunology]

    Abstract
    Virtual Conference Exhibition: Pluripotent Stem Cells
    REVIEWS

    Organoid Cultures for Cancer Modeling

    Investigators review primary tissue-derived and pluripotent stem cell-derived cancer organoid models and detail how they have the potential to inform personalized medical approaches in different organ contexts.
    [Cell Stem Cell]

    Abstract

    Recent Advances in Endocrine Organoids for Therapeutic Application

    The authors highlight recent advances in endocrine organoids for a wide range of therapeutic applications and discuss the gap between preclinical and clinical research.
    [Advanced Drug Delivery Reviews]

    AbstractGraphical Abstract

    Localized Immunomodulation Technologies to Enable Cellular and Organoid Transplantation

    Scientists describe recent advances in engineering solutions for the development of localized immunomodulation techniques focusing on cellular and organoid transplantation.
    [Trends In Molecular Medicine]

    Abstract
    INDUSTRY AND POLICY NEWS

    NIH Mandate That Foreign Partners of US Scientists Regularly Submit All Data Stirs Outcry

    Many US biomedical researchers and their collaborators abroad have reacted with alarm to a new NIH requirement that foreign groups send their NIH partners copies of their lab notebooks and other raw data at least every few months.
    [Science Insider]

    Editorial
    FEATURED EVENT

    Angiogenesis and Angiostability in Development, Disease, and Engineered Tissues

    July 30 – August 4, 2023
    Newport, Rhode Island, United States

    > See All Events

    JOB OPPORTUNITIES

    Technician/Senior Technician – Stem Cell Biology & Functional Genomics

    Human Technopole – Milan, Italy

    Postdoctoral Researchers – Molecular & Biophysical Aspects of Skin and Mucosa Barriers

    Malm̦ University РMalm̦, Sweden

    Postdoctoral Fellow – Cell-Based Immuno-Oncology Drug Development

    Centre for Oncology and Immunology – Hong Kong, Hong Kong

    Postdoctoral Intramural Research Fellowship Position – Orthobunyaviruses

    National Institute of Allergy and Infectious Diseases – Hamilton, Montana, United States

    Assistant/Associate Professor – Genome Editing and Therapeutics

    Center for Disease Neurogenomics at the Icahn School of Medicine – Manhattan, New York, United States

    > See All Jobs

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