 | | Vol. 5.24 – 20 June, 2024 |
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| Researchers evaluated whether patient-derived organoids (PDO) could be implemented in clinical practice to benefit patients with advanced refractory PDAC. 54 PDOs were generated from 87 pretreated patients.
[Gastroenterology] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists integrated organoid and organ-on-a-chip technology to develop an advanced human organoid model. By employing an asymmetric stimulation with growth factors, they greatly enhanced tissue longevity and replicated in vivo-like diversity and patterning of proliferative and differentiated cell types.
[Cell Stem Cell] |
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| Neural progenitor cells of the cochlea and auditory cortex were derived from human embryos to generate region-specific organoids and these organoids were assembled in a nanofiber-combined 3D system.
[Advanced Science] |
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| Through the regulation of multiple parameters, investigators have generated a more highly standardized and efficient method to yield consistently pure populations of retinal organoids of consistent size and shape across multiple cell lines.
[Proceedings of The National Academy of Sciences of The United States of America] |
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| Researchers assessed the impact of brain organoid-derived small extracellular vesicles on various behaviors of the MDA-MB-231 cell line, chosen as a representative of triple-negative breast cancer in a 3D microfluidic model.
[Lab On A Chip] |
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| Scientists used cortical neurons and brain organoids from ataxia telangiectasia-patient iPSC and gene-corrected isogenic controls to reveal levels of mitochondrial dysfunction, oxidative stress, and senescence that varied with developmental maturity.
[Neurobiology of Disease] |
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| Researchers screened and optimized culture media, employing three-dimensional techniques to construct human-derived oral squamous cell carcinoma organoid models in vitro.
[Oral Diseases] |
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| Scientists investigated the effects of benzoic acid on the intestinal barrier and the differentiation of intestinal stem cells, employing in vivo piglet and in vitro intestinal organoid models.
[Veterinary Microbiology] |
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| Investigators established human colon cancer-derived organoids and investigated clonal dynamics during liver metastasis development by tracking barcode-labeled subclones.
[Journal of Biochemistry] |
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| The authors summarize the recent advancements in the use of organoids for studying renal cell carcinoma, focusing on their cultivation, potential applications, and inherent limitations.
[BMC Urology] |
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| A research team from the LKS Faculty of Medicine at the University of Hong Kong (HKUMed) has developed ‘Bionic Liver-in-Cube: A Comprehensive Precise Theranostics for Liver Cancer and Diseases’. Using 3D bioprinting, it can mimic liver tumors of patients for evaluation of emerging therapies.
[The University of Hong Kong (EurekAlert!)] |
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| August 13-17, 2024
Long Island, New York, United States |
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| | Ramona Optics – Durham, North Carolina, United States |
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| | Penn Medicine – Philadelphia, Pennsylvania, United States |
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| | University of Luxembourg – Esch-sur-Alzette, Luxembourg |
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| | University of Antwerp – Antwerp, Belgium |
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| | Columbia University – New York, New York, United States |
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