 | | Vol. 13.26 – 5 July, 2022 |
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| Researchers identified the BMP inhibitor GREM1 as a key regulator of cellular heterogeneity in pancreatic cancer in humans and mice.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| HHEX cooperated with the pioneer transcription factors (TFs) FOXA1, FOXA2 and GATA4, shared by both pancreas and liver differentiation programmes, to promote pancreas commitment, and this cooperation restrained the shared TFs from activating alternative lineages.
[Nature Cell Biology] |
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| The authors developed and validated an augmented conformal coating (CC) method that achieved hydrogel CCs around islets at physiological pH for improved cytocompatibility, with polyethylene glycol hydrogels for increased biocompatibility and with fivefold increase in encapsulation throughput for enhanced scalability.
[Science Advances] |
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| Scientists deleted the proinflammatory gene encoding 12/15-lipoxygenase in β cells of non-obese diabetic mice at a pre-diabetic time point when islet inflammation was a feature.
[Cell Reports] |
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| Using transcriptome and chromatin immunoprecipitation profiling of PDAC cells treated with the MEK inhibitor, Trametinib, researchers identified transcriptional antagonism between c-MYC and the master transcription factors for lysosome gene expression, the MiT/TFE proteins.
[Cancer Discovery] |
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| Metabolic stress induced ACSS2 expression, which is associated with worse prognosis in pancreatic cancer. ACSS2 knockout significantly suppressed cell proliferation in 2D and 3D models.
[Gastroenterology] |
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| Through a Phos-tag-based kinome-wide screen, the authors identified microtubule affinity-regulating kinase proteins (MARK2) as a critical regulator for paclitaxel chemosensitivity in PDAC.
[Oncogene] |
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| Investigators reported that riluzole inhibited pancreatic cancer cell growth and had no effect on human pancreatic normal ductal epithelial cells.
[Scientific Reports] |
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| By epitranscriptomic analysis, researchers reported that polo-like kinase 1 was an important hub gene defining patient prognosis in pancreatic cancer and that RNA methylation was involved in regulating its cell cycle-specific expression.
[Scientific Reports] |
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| The authors highlight how pancreatic islet organoids-on-a-chip have improved the reproducibility of stem cell differentiation and organoid culture.
[Journal of Nanobiotechnology] |
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| Scientists discuss recent findings on the role of miRNAs in the activation of cancer-associated fibroblasts during the progression of PDAC and its response to therapy
[Journal of Physiology and Biochemistry] |
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| Investigators elaborate on the regulatory mechanisms and signaling pathways of ferroptosis in pancreatic cancer, with the intention of delivering directions and new ideas for the treatment of pancreatic cancer.
[Acta Histochemica] |
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| Phanes Therapeutics, Inc. announced that the US FDA has granted orphan drug designation to PT886 for the treatment of pancreatic cancer.
[Phanes Therapeutics, Inc.] |
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| Vertex Pharmaceuticals Incorporated announced that the US FDA has lifted the clinical hold placed on the Phase I/II clinical trial of VX-880, a stem cell-derived, fully differentiated pancreatic islet cell replacement therapy for people with type 1 diabetes with impaired hypoglycemic awareness and severe hypoglycemia.
[Vertex Pharmaceuticals Incorporated] |
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| October 9 – 13, 2022
Cairns, Australia |
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| | The University of Tennessee Health Science Center – Memphis, Tennessee, United States |
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| | University of California, San Francisco – San Francisco, California, United States |
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| | University Health Network – Toronto, Ontario, Canada |
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| | Uppsala University – Uppsala, Sweden |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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