 | | Vol. 13.25 – 28 June, 2022 |
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| Single-cell RNA sequencing revealed the heterogeneity of pancreatic stellate cell (PSCs) and identified very-low-density lipoprotein receptor+ PSCs that were characterized by a higher lipid metabolism.
[Immunity] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Using total internal reflection fluorescence microscopy, scientists monitored insulin granule exocytosis in primary islet cells to dissect the effect of dopamine.
[Diabetes] |
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| Researchers reported that methionine sulfoxide reductase A (MSRA) expression was decreased in the metastatic tumors of PDAC patients, whereas MSRA loss in primary PDA cells promoted migration and invasion.
[Molecular Cell] |
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| Scientists applied single-cell sequencing technologies to reveal inherent heterogeneity in assumptively monoclonal pancreatic cancer cell lines and patient-derived organoids.
[Nature Communications] |
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| The authors reported that in patient-derived organoid models in vitro and patient-derived xenograft models in vivo, mitochondrial calcium uniporter (MCU)-high PDAC demonstrated increased sensitivity to SLC7A11 inhibition compared with MCU-low tumors.
[Cancer Research] |
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| Researchers reported that aortic carboxypeptidase–like protein (ACLP) was mainly expressed in cancer-associated fibroblasts (CAFs) but not in cancer cells and highly expressed in pancreatic ductal adenocarcinoma (PDAC) tissues.
[Cancer Letters] |
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| Investigators reported that S100A11 expression was increased in PDAC and significantly associated with worse prognosis and disease progression.
[Cell Death & Disease] |
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| Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like (APOBEC3C)-overexpressing cell lines were generated to substantiate the effects of APOBEC3C on the PDAC genome, including alterations in single-nucleotide variant classes and the formation of kataegis regions.
[Oncogenesis] |
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| Scientists reported that disulfiram formed potent complexes with copper, inhibited cell proliferation, and induced apoptosis in human pancreatic cancer cells, which was detected by flow cytometry and western blotting.
[Human Cell] |
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| Researchers reported that β2-adrenergic receptor recruited Cdc42 in response to isoproterenol exposure in PDAC cells.
[Journal of Molecular Histology] |
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| Investigators discuss the metabolic pathways utilized by pancreatic cancer cells and stromal cells, providing examples of how they could present novel targets for therapeutic interventions and elaborating on how interactions between the various cell types affect their metabolism.
[International Journal of Oncology] |
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| The authors classify miRNAs and signaling pathways related to pancreatic cancer (PC) chemoresistance, suggesting new therapeutic approaches to overcome PC chemoresistance.
[Pathology Research and Practice] |
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| Panavance Therapeutics, Inc. announced the US FDA has granted Orphan Drug Designation to GP-2250 for the treatment of all forms of pancreatic cancer.
[Panavance Therapeutics, Inc.] |
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| December 3 – 7, 2022
Washington, DC, United States |
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| | University Health Network – Toronto, Ontario, Canada |
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| | National University of Ireland Galway – Galway, Ireland |
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| | The Ohio State University Comprehensive Cancer Center – Columbus, Ohio, United States |
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| | Uppsala University – Uppsala, Sweden |
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| | The University of British Columbia – Vancouver, British Columbia, Canada |
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