 | | Vol. 13.27 – 12 July, 2022 |
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| The authors used a human embryonic stem cell differentiation system, in which TET1/TET2/TET3 triple knockout cells displayed severe defects in pancreatic β-cell specification.
[Nature Communications] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Scientists identified three tRNA-derived fragments abundant in neonatal rat islets originating from 5′ halves of histidine and glutamate tRNAs. Their inhibition in these islets reduced β cell proliferation and insulin secretion.
[Cell Reports] |
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| Investigators indicated that subsets of ductal cells were able to gain β-cell identity and reflected a form of compensation during the adaptation to insulin resistance in both physiological and pathological states.
[JCI Insight] |
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| Researchers investigated the effects of the mitoribosomal gene on β-cell function and glucose homeostasis and found deregulation of most mitoribosomal genes in islets from individuals with type 2 diabetes, including partial downregulation of CRIF1.
[Experimental & Molecular Medicine] |
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| By integrating genomic analysis with an arrayed RNAi druggable genome screen and drug profiling of a KRAS/TP53 mutant PDAC cell line derived from a patient-derived xenograft, scientists identified numerous targetable vulnerabilities that revealed both known and novel functional aspects of pancreatic cancer biology.
[Cancer Research] |
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| The authors reported the effects of deleting the essential autophagy gene Atg7 in a model of PDAC, in which mutant KrasG12D and mutant Trp53172H were induced in adult tissue leading to metastatic PDAC.
[Proceedings of the National Academy of Sciences of the United States of America] |
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| Researchers investigated the impact of cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) expression and the presence of cancer-associated fibroblasts upon immune cell infiltration in PDACs.
[Scientific Reports] |
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| Immunohistochemistry results of tumor tissue chips together with gene expression omnibus sequencing files confirmed that lipocalin-2 was highly expressed in pancreatic carcinoma compared with that in normal tissues.
[Human Cell] |
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| To understand the pattern of protein kinase C (PKC) enzymes in PDAC, investigators examined all PKC family member genes expression in PDAC and matched normal tissues.
[Pathobiology] |
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| Scientists review the implications of extracellular vesicle (EV) release from β cells for type 1 diabetes (T1D) pathogenesis, how EVs and their cargo might be leveraged as biomarkers of this process, and how EVs might be engineered as a therapeutic candidate to counter T1D outcomes.
[Molecular Metabolism] |
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| Investigators discuss recent updates on islet transplantation to overcome donor shortage and immunosuppressant-related complications and share their perspectives on future β cell replacement therapy.
[Journal of Diabetes investigation] |
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| The authors discuss the potential role that exosomes and their specific biofactors may play to improve and sustain the function of this bioartificial construct.
[Annals of Biomedical Engineering] |
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| Inventiva announced the screening in the US of the first patient in its LEGEND Phase IIa combination trial with lanifibranor and empagliflozin in patients with non-alcoholic steatohepatitis (NASH) and type 2 diabetes (T2D).
[Inventiva] |
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| Just a week after Vertex’s stem cell therapy to treat type 1 diabetes was released from an FDA clinical hold, the company is clearing out potential competition by buying ViaCyte for $320 million.
[Fierce Biotech] |
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| November 2 – 4, 2022
Lyon, France |
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| | Albert Einstein College of Medicine – Bronx, New York, United States |
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| | The Chinese University of Hong Kong – Hong Kong, China |
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| | The University of Tennessee Health Science Center – Memphis, Tennessee, United States |
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| | University Health Network – Toronto, Ontario, Canada |
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| | Uppsala University – Uppsala, Sweden |
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