 | | Vol. 14.35 – 12 September, 2023 |
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| Scientists integrated over 300,000 cells from nine scRNA-seq datasets consisting of 56 samples, varying in age, sex, and diabetes models, including an autoimmune type 1 diabetes model, a glucotoxicity/lipotoxicity type 2 diabetes model, and a chemical streptozotocin β-cell ablation model.
[Nature Metabolism] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers investigated whether the administration of exogenous T3 can counteract the cellular remodeling that occurs in diabetic cardiomyocytes, podocytes and pancreatic beta cells.
[iScience] |
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| Researchers investigated the potential of human induced pluripotent stem cells to lead to the development of the different β-cells subtypes in honeycomb microwell-based 3D spheroids.
[Molecular Omics] |
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| The authors explored the potential role of manuka honey in pancreatic regeneration in alloxan-induced diabetic rats by accessing the pancreatic histology and levels of relevant transcription factors, including MAFA, PDX-1, INS-1, INS-2, NEUROG3, NKX6-1, and NEUROD.
[Heliyon] |
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| Scientists utilized two kinds of streptozotocin-induced diabetes model mice by changing the administration timing in order to examine the time course of maturation of hSC-islets and the effects of hyperglycemia on their maturation.
[Heliyon] |
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| Investigators constructed the stably expressing cell lines with shRUNX1 and RUNX1, and successfully established Gemcitabine (GEM)-resistant cell line. The role of RUNX1 in GEM resistance was determined by CCK8 assay, plate colony formation assay and apoptosis analysis in vitro and in vivo.
[Journal Of Experimental & Clinical Cancer Research] |
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| Overexpression of CPT1A increased cell proliferation and promoted EMT and glycolytic metabolism in PAAD cells. Mechanistically, CPT1A was able to bind to Snail and facilitate PAAD progression by regulating Snail stability.
[iScience] |
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| Overexpression of K-Ras elevated PI3K signaling in MSCs, and K-Ras/PI3K-activated MSC-derived CM reduced the proliferation and migration of tumor cells, as well as the growth of ex vivo freshly isolated human PDAC cultures.
[Scientific Reports] |
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Expression of CXCR4 in specimens from 33 patients with PDAC was evaluated by immunohistochemistry techniques and matched with clinicopathological parameters, overall and disease-free survival rates.
[World Journal Of Surgical Oncology] |
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| Investigators review the transition from EUS-FNA to FNB, compare each test, and discuss the current status and issues in genomic analysis of hepatobiliary–pancreatic cancers using Endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA)/fine-needle biopsy (FNB) specimens.
[Journal Of Gastroenterology] |
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| When Svetlana Mojsov heard the spring 2021 announcement, she was startled. The Canada Gairdner International Award, a prestigious biomedical research prize, would be bestowed on three scientists for work underpinning the diabetes and obesity drugs that have exploded in popularity in recent years. “I was really upset,” recalls Mojsov, a chemist at Rockefeller University.
[ScienceInsider] |
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| Researchers are marking another milestone in the long road toward making islet cell transplantation a reality for people with type 1 diabetes, which has long been pursued as a possible cure.
[Miller School of Medicine] |
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| October 4 – 6, 2023
Paris, France |
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| | University of California, Los Angeles – Los Angeles, California, United States |
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| | Northwestern University – Chicago, Illinois, United States |
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| | University of California – Los Angeles, California, United States |
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| | The Sidney Kimmel Cancer Center – Philadelphia, Pennsylvania, United States |
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| | Cedars-Sinai – Los Angeles, California, United States |
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