 | | Vol. 14.01 – 10 January, 2023 |
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| Scientists reported an unexpected role for copper in promoting ferroptotic cell death, but not cuproptosis, by inducing macroautophagic/autophagic degradation of glutathione peroxidase 4 (GPX4).
[Autophagy] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers reported that knockdown of calmodulin-regulated Spectrin-Associated Protein (CAMSAP)2 in primary β-cells reduced total insulin content and attenuated GSIS without affecting the releasability of insulin vesicles.
[iScience] |
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| Chronic exposure of INS-1 cells or human pancreatic 1.1b4 β-cells to perfluorooctane sulfonate stimulated the small G-protein RAC1-guanosine triphosphate-dependent nicotinamide adenine dinucleotide phosphate oxidase subunit expression and activation.
[Environmental Pollution] |
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| To identify antifibrotic drug targets, investigators integrated progressive transcriptomic and morphological responses that accompany hepatic stellate cells activation in advanced disease using single-nucleus RNA sequencing and tissue clearing in a robust murine NASH model.
[Science Translational Medicine] |
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| Scientists generated a unique Esai-CRISPR-based mucin4 (Muc4) conditional knockout murine model to evaluate its effect on PDAC pathology.
[Oncogene] |
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| To generate specific antibodies that bind to proteins expressed on the surface of pancreatic cancer cells, researchers immunized mice with human pancreatic cancer MIA PaCa-2 cells, and isolated a hybridoma that produces a monoclonal antibody, named 12–13.8.
[Biochimie] |
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| PANC-1, MIA PaCa-2, and H1299 cells were treated with rodent islet amyloid polypeptide (IAPP), and the IAPP analogs pramlintide and davalintide, and assayed for changes in proliferation, death, and glycolysis.
[Molecular Metabolism] |
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| miR-455-5p levels were first tested by RT-qPCR in pancreatic cancer (PaC) tissues or cells. Subsequently, PaC cell-related functions were identified through CCK-8, Transwell, and Western blotting.
[Cancer Biotherapy And Radiopharmaceuticals] |
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| HNF4G and IGF2BP2 expressions in pancreatic cancer were examined. The relationship between HNF4G expression and pancreatic cancer patients’ clinicopathological characteristics was evaluated.
[Clinical And Translational Oncology] |
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| The authors provide evidence that the diverse tumor microenvironments of pancreatic cancer is a central executor of various different context-dependent modes of immunosuppression.
[Cancer Discovery] |
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| Investigators propose that a significant proportion of individuals may harbor an immune profile that renders them susceptible to developing type 2 diabetes.
[Trends In Immunology] |
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| ROCK belongs to the AGC family of Ser/Thr protein kinases that are involved in many cellular processes. ROCK-driven actomyosin contractility regulates cytoskeletal dynamics underpinning cell migration, proliferation, and survival in many cancer types.
[Trends In Cancer] |
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| More than 100,000 people in England and Wales with type 1 diabetes could soon be offered new technology to manage their condition on the NHS. The system uses a glucose sensor under the skin to automatically calculate how much insulin is delivered via a pump.
[BBC] |
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| Congratulations to Diabetes UK-funded researcher Professor Roy Taylor, who has been awarded an MBE in the New Year Honors list, recognizing his world-leading work in diabetes research.
[Diabetes UK] |
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| February 19 – 22, 2023
Banff, Alberta, Canada |
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| | Aspect Biosystems – Vancouver, British Columbia, Canada |
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| | Stanford Medicine – Stanford, California, United States |
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| | University Medical Center Freiburg – Freiburg, Germany |
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| | Johns Hopkins University – Baltimore, Maryland, United States |
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| | University of Nebraska Medical Center – Omaha, Nebraska, United States |
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