 | | Vol. 15.26 – 5 November, 2024 |
| |
|
|
| Investigators reported for the first time autologous transplantation of chemically induced pluripotent stem cell-derived islets into a patient with type 1 diabetes with immunosuppression as part of an exploratory clinical study.
[Cell] |
|
|
|
 | | PUBLICATIONSListed by the impact factor of the journal |
| |
|
|
| The authors profiled single-nuclei RNA along with enhancer marks H3K4me1 or H3K27ac in islets from lean or obese mice. They identified distinct gene signatures and enhancer states correlating with β cell dysfunction trajectory.
[Nature Communications] |
|
|
|
| Investigators described in vitro characterization of the secretory function of pancreatic islets, derived from transgenic pigs expressing the glucagon-like-peptide-1-1M3R cassette under the porcine insulin promoter, and their usage to treat insulin-dependent diabetes in an immunodeficient mouse model.
[Proceedings of The National Academy of Sciences of The United States of America] |
|
|
|
| The aim of this Phase II, placebo-controlled, double-blinded, randomized clinical trial was to investigate the efficacy and safety of fenofibrate in adults and adolescents with newly diagnosed type 1 diabetes.
[Diabetologia] |
| |
|
|
| Investigators reported a previously unknown chemo-induced symbiotic signaling circuit that adaptively conferred chemoresistance in patients and mice with advanced PDAC.
[Cell Discovery] |
|
|
|
| Researchers tested prophylactic and therapeutic vaccination against ADAM12 in murine pancreatic ductal adenocarcinoma and observed delayed tumor growth along with a reduction in cancer-associated fibroblasts and tumor desmoplasia.
[EMBO Molecular Medicine] |
|
|
|
| Baseline plasma levels of chemokine chemokine ligand 3 (CCL3) were integrated with clinical outcomes in PDAC patients treated with galunisertib plus gemcitabine or placebo plus gemcitabine.
[NPJ Precision Oncology] |
|
|
|
| Scientists demonstrated that KRASG12D induced the expression of an endogenous inhibitor of protein phosphatase 2A (PP2A) activity, cancerous inhibitor of PP2A (CIP2A), and phosphorylation of the PP2A substrate, c-MYC.
[Oncogene] |
|
|
|
| Investigators unveiled a multistep process for interleukin 17 receptor B (IL-17RB) upregulation at the invasive margin, which occured through direct communication between tumor cells and fibroblasts.
[Cancer Gene Therapy] |
|
|
|
| Researchers created a recombinant Newcastle disease virus containing the PTEN gene to investigate its PDAC cell-killing and tumor-suppression effects in PDAC cells transplanted into mice.
[Molecular Therapy Oncology] |
|
|
|
| Scientists investigated the utility of patient-derived organoids (PDOs) to overcome the obstacles of detecting somatic mutations and enhance somatic mutation identification. Surgically resected PDAC tumors and their paired PDOs from 21 patients were examined.
[Scientific Reports] |
|
|
|
|
| The authors summarize the evidence regarding the epidemiology of type 1 diabetes mellitus in older adults as well as the genetics, immunology, and diagnostic challenges.
[Nature Reviews Endocrinology] |
|
|
|
|
| With a $50 million gift from Richard and Susan Rogel, the University of Michigan Health Rogel Cancer Center aims to revolutionize how the world detects, treats, and ultimately cures pancreatic cancer.
[Michigan Medicine] |
|
|
|
| The University of Oxford has been given a share of £2 million to study whether saliva from parasitic ticks could remove the need for immunosuppressant drugs when treating type 1 diabetes.
[BBC] |
|
|
|
|
| December 2-3, 2024
Toronto, Ontario, Canada & Online |
|
|
|
|
|
| | University of New Mexico – Albuquerque, New Mexico, United States |
|
|
|
| | City of Hope – Monrovia, California, United States |
|
|
|
| | University of Pennsylvania – Philadelphia, Pennsylvania, United States |
|
|
|
| | University of Oklahoma Health Sciences Center – Oklahoma City, Oklahoma, United States |
|
|
|
| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
|
|
|
|
Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
