 | | Vol. 16.00 – 7 January, 2025 |
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| Investigators characterized the genomic and clinical correlates of outcomes in PDAC. They showed that a genomic subtype of KRAS wild-type tumors was associated with early disease onset, distinct somatic and germline features, and significantly better overall survival.
[Nature Medicine] |
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 | | PUBLICATIONSListed by the impact factor of the journal |
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| A novel NIR-II nanosensor DNPS for nitric oxide with fluorescence/photoacoustic imaging capability was developed to explore the mechanism by which diabetes promoting breast cancer progression.
[Advanced Materials] |
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| Investigators found that trait-associated variants in the glucose-6-phosphatase catalytic subunit 2 (G6PC2) promoter were located in open chromatin not just in β but also in α cells and documented allele-specific G6PC2 expression of linked variants in human α cells.
[Science Translational Medicine] |
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| Scientists identified SPARC (osteonectin), Cwcv and Kazal-like domains proteoglycan 2 (SPOCK2), an extracellular matrix protein, as an inhibitor of immature β-cell proliferation. Human β-cells lacking SPOCK2 presented elevated matrix metalloproteinase-2 (MMP2) expression and activity.
[Experimental & Molecular Medicine] |
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| The authors expored the efficacy and safety of sivelestat (SV) in the treatment of severe acute pancreatitis (SAP) with systemic inflammatory response syndrome. Although SV did not reduce the mortality of patients with SAP, it reduced the length of ventilator use and ICU stay.
[Scientific Reports] |
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| Scientists evaluated the effects of resveratrol (RES) and β‐carotene (βC) on L-arginine-induced acute pancreatitis (AP) in rats. RES and βC conferred significant effects against L-arginine-induced AP by reducing oxidative stress, preserving pancreatic islet integrity, and suppressing inflammatory responses.
[Scientific Reports] |
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| The authors highlighted the multiple ways in which MICAL2 impacted PDAC biology and provided a foundation for future investigations into the potential of targeting MICAL2 for therapeutic intervention.
[Cancer Research] |
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| Investigators applied a live imaging approach to organoids derived from 10 pancreatic ductal adenocarcinoma (PDAC) patients to comprehensively understand their heterogeneous growth potential and drug responses.
[Cancer Science] |
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| Targeting the crosstalk between pancreatic cancer and the nervous system, either peripherally or centrally, holds promise in cancer treatment, pain relief, and improved quality of life.
[Trends in Neurosciences] |
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| A common pathophysiological characteristic in type 2 diabetes mellitus is the presence of insulin resistance and chronic low-grade inflammation which can damage the liver, brain, and muscles, and increase the risk of some cancers.
[Trends in Endocrinology and Metabolism] |
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| Dr. Howe Mao has been awarded a $260,000 Clinical Research Training Fellowship to improve molecular understanding of pancreatic cancer.
[University of Auckland] |
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| February 11-12, 2025
Cambridge, England, United Kingdom |
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| | University of Wisconsin–Madison – Madison, Wisconsin, United States |
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| | Dana-Farber Cancer Institute – Boston, Massachusetts, United States |
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| | Columbia University – New York, New York, United States |
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| | University of Alabama at Birmingham – Birmingham, Alabama, United States |
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| | IBSA Foundation for Scientific Research – Lugano, Switzerland |
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