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Pulmonary Cell News| Pancreatic Cell News 9.14 April 10, 2018 | |
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TOP STORYTargeting Galectin-1 Inhibits Pancreatic Cancer Progression by Modulating Tumor–Stroma Crosstalk The authors identified galectin-1, a glycan-binding protein that is highly overexpressed in pancreatic ductal adenocarcinoma stroma, as a major driver of pancreatic cancer progression. [Proc Natl Acad Sci USA] Abstract | |
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PUBLICATIONS(Ranked by impact factor of the journal)DIABETES & PANCREATITIST3 Induces Both Markers of Maturation and Aging in Pancreatic β-Cells Scientists showed thyroid hormone (T3) increased p16Ink4a (a β-cell senescence marker and effector) mRNA in rodent and human β-cells. [Diabetes] Abstract The authors showed that in the process of activating c-Jun N-terminal kinase, aggregation prone human islet amyloid polypeptide also activates an upstream apoptosis signal regulating kinase-1 with concomitant decrease in intracellular levels of reduced glutathione. [Biochim Biophys Acta] Abstract Investigators elucidated the effects and possible mechanisms of low-dose tributyltin on the growth and function of pancreatic β-cells and glucose metabolism in mice. [Sci Rep] Full Article Researchers assessed potential mitochondrial permeability transition pore involvement in oxidant-induced effects on pancreatic acinar cell bioenergetics and fate. [J Biol Chem] Abstract | Full Article Substance P Preserves Pancreatic β-Cells in Type 1 and Type 2 Diabetic Mice Investigators demonstrated that chronic systemic treatment with substance P restored the mass of β-cells both in nonobese diabetic mice with type 1 diabetes or db/db mice with type 2 diabetes. [Biochem Biophys Res Commun] Abstract PANCREATIC CANCERAge-Related Islet Inflammation Marks the Proliferative Decline of Pancreatic Beta-Cells in Zebrafish By comparing beta-cells from younger and older zebrafish, the investigators showed that the aging islets exhibit signs of chronic inflammation. [Elife] Full Article Simvastatin Inhibits Sonic Hedgehog Signaling and Stemness Features of Pancreatic Cancer Scientists found that simvastatin inhibited viability, stemness, tumor growth and metastasis and that it enhanced the efficacy of gemcitabine. [Cancer Lett] Abstract Investigators examined the potential effects of heme oxygenase-1 (HO-1) on pancreatic cancer cell proliferation and sensivity to gemcitabine. Furthermore, the role of the sonic hedgehog (SHH) signaling pathway in the regulatory effects of HO-1 on pancreatic cancer progression were examined. [Int J Oncol] Abstract Molecular biomarkers are an important method for diagnostic use in pancreatic cancer. Researchers used data from three mRNA microarray datasets and a microRNA dataset (GSE16515, GSE15471, GSE28735, and GSE41372) to identify potential key genes. [Transl Oncol] Full Article Scientists studied the role of pyruvate kinase isozyme M2 in the interactions between pancreatic cancer cells and pancreatic stellate cells [Dig Dis Sci] Abstract Scientists evaluated the role of krüppel-like factor 9 (KLF9) in pancreatic ductal adenocarcinoma (PDAC). Overexpression of KLF9 significantly inhibited proliferation and clone formation in PDAC cells, while silencing KLF9 expression dramatically promoted this effect in vitro. [Biochem Biophys Res Commun] Abstract | |
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REVIEWSMechanisms of Action and Therapeutic Application of Glucagon-Like Peptide-1 The author reviews the circuits engaged by endogenous versus pharmacological glucagon-like peptide-1 (GLP-1) action, highlighting key GLP-1 receptor-positive cell types and pathways transducing metabolic and non-glycemic GLP-1 signals. [Cell Metab] Abstract Visit our reviews page to see a complete list of reviews in the pancreatic cell research field. | |
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INDUSTRY NEWSEli Lilly and Company and Sigilon Therapeutics announced a global collaboration to develop encapsulated cell therapies for the potential treatment of type 1 diabetes. [Eli Lilly and Company] Press Release £1 Million Funds Seven Grants for Pancreatic Cancer Research The grants take the charity’s research portfolio to 52 projects worth over £8 million, plus a further £2 million committed to the world’s first national pancreas tissue bank, created in 2016 to further accelerate research progress. [EurekAlert] Press Release Zucara Therapeutics Inc. has secured US$3.9 million in non-dilutive funding from The Leona M. and Harry B. Helmsley Charitable Trust. [Zucara therapeutics Inc.] Press Release WellDoc® announced a pilot program in the Providence Health & Services Oregon/SW Washington region to examine the use of WellDoc’s BlueStar®, an FDA-cleared, proven digital therapeutic for individuals with type 2 diabetes. [WellDoc, Inc] Press Release | |
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POLICY NEWSWeb of Science Owner Buys Tool that Offers One-Click Access to Journal Articles The owner of the large scholarly search engine Web of Science — Clarivate Analytics — has bought a start-up company whose tool gives researchers one-click, legal access to journal articles even when off campus. [Nature News] Editorial India Creates Unique Tiered System to Punish Plagiarism The Indian government has adopted its first regulations on academic plagiarism—rules that some researchers say are too lenient and others fear go too far and will be difficult to implement. [ScienceInsider] Editorial Got Data? Survey of 2017 March for Science Doesn’t Make the Grade A group of researchers has released the first results of a large survey of those who participated in and supported last year’s March for Science. Some social scientists say the analysis is fundamentally flawed and reflects poorly on an organization that champions scientific rigor. [ScienceInsider] Editorial Science’s Vast Gender Pay Gap Revealed in UK Wage Data Many UK science employers pay women much less than men, and some institutions are far less equal than others, according to an analysis conducted by Nature of statistics released last week. [Nature News] Editorial
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EVENTSNEW Goodbye Flat Biology: In Vivo Inspired Cancer Biology and Therapy Visit our events page to see a complete list of events in the community.
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JOB OPPORTUNITIESResearch Fellow/Associate – Diabetes Research (Rutgers University) Postdoctoral Position – Pancreatic Cancer (Fox Chase Cancer Center) Postdoctoral Scholar – Cancer (University of California, San Francisco) Postdoctoral Position – Protein Biochemistry (Vlaams Instituut voor Biotechnologie) Postdoctoal Fellow – Pancreatic Cell (Inserm) Postdoctoral Fellow – Diabetes and Pancreatic Islet Biology (Vanderbilt University) Postdoctoral Scientist – Epigenetic Mechanisms (Geneva University) Postdoctoral Fellow – Epigenetic Regulation of Pancreatic Beta-Cell Mass (City of Hope) Postdoctoral Positions – Pancreatic Cancer Cells (Fox Chase Cancer Center) Recruit Top Talent: Reach potential candidates by posting your organization’s career opportunities on the Connexon Creative Job Board at no cost.
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