Pulmonary Cell News Volume 11.29 | Jul 28 2022

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    Danielle Corrigan
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    2022-07-28 | PULCN 11.29


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 11.29 – 28 July, 2022
    TOP STORY

    Genome-Wide Bidirectional CRISPR Screens Identify Mucins As Host Factors Modulating SARS-CoV-2 Infection

    Researchers conducted genome-wide CRISPR knockout and activation screens in human lung epithelial cells with endogenous expression of the SARS-CoV-2 entry factors ACE2 and TMPRSS2.
    [Nature Genetics]

    Full Article

    ON1098-728 x 90
    PUBLICATIONSRanked by the impact factor of the journal

    SARS-CoV-2 Nucleocapsid Protein Triggers Hyperinflammation via Protein-Protein Interaction-Mediated Intracellular Cl− Accumulation in Respiratory Epithelium

    Investigators demonstrated that SARS-CoV-2 nucleocapsid protein could interact with Smad3, which downregulated cystic fibrosis transmembrane conductance regulator expression via microRNA-145.
    [Signal Transduction and Targeted Therapy]

    Full Article

    Dysfunctional ERG Signaling Drives Pulmonary Vascular Aging and Persistent Fibrosis

    Researchers performed an epigenetic and transcriptional analysis of lung endothelial cells from young and aged mice during the resolution or progression of bleomycin-induced lung fibrosis.
    [Nature Communications]

    Full Article

    Regulatory Roles of NAT10 in Airway Epithelial Cell Function and Metabolism in Pathological Conditions

    Scientists demonstrated that NAT10 expression increased in human lung epithelia and varied among epithelial types, challenges, and diseases.
    [Cell Biology and Toxicology]

    AbstractGraphical Abstract

    Mycoplasma pneumoniae Downregulates Reck To Promote Matrix Metalloproteinase-9 Secretion by Bronchial Epithelial Cells

    The authors investigated the mechanism of matrix metalloproteinase-9 secretion in airway epithelial cells infected with Mycoplasma pneumoniae.
    [Virulence]

    Full Article

    Kukoamine a Inhibits C-C Motif Chemokine Receptor 5 To Attenuate Lipopolysaccharide-Induced Lung Injury

    Investigators elucidated the mechanism underlying the effects of Kukoamine A treatment on endotoxin-induced lung injury/inflammation.
    [Drug Development Research]

    Abstract

    Effect of Baricitinib on the Epithelial-Mesenchymal Transition of Alveolar Epithelial Cells Induced by IL-6

    Scientists explored the mechanism of IL-6 on the epithelial-mesenchymal transition (EMT) of alveolar epithelial cells and inhibition JAK/STAT pathway with Baricitinib on the EMT of alveolar epithelial cells.
    [International Immunopharmacology]

    Abstract

    SIRT1-Mediated p53 Deacetylation Inhibits Ferroptosis and Alleviates Heat Stress-Induced Lung Epithelial Cells Injury

    To investigate whether ferroptosis was involved in heat stroke-acute lung injury, researchers established a heat stroke model of mice and mouse lung epithelial-2 cells.
    [International Journal of Hyperthermia]

    Full Article

    Targeting De Novo Lipogenesis and the Lands Cycle Induces Ferroptosis in KRAS-Mutant Lung Cancer

    Investigators demonstrated that FASN, the rate-limiting enzyme in fatty acid synthesis, while being dispensable in EGFR-mutant or wild-type KRAS lung cancer (LC), was required for the viability of mutant KRAS LC cells.
    [Nature Communications]

    Full Article

    RGS6 Suppresses TGF-β-Induced Epithelial–Mesenchymal Transition in Non-Small Cell Lung Cancers via a Novel Mechanism Dependent on Its Interaction with SMAD4

    Researchers discovered a novel function of RGS6 in suppressing TGF-β-induced epithelial–mesenchymal transition of NSCLC cells and in vivo NSCLC metastasis.
    [Cell Death & Disease]

    Full Article

    Generate Functional Alveolar Organoids with PneumaCult â„¢
    REVIEWS

    Microbiota and Lung Cancer

    The authors present a context for the basic mechanisms and molecular functions of the airway microbiome in oncogenesis, in an effort to prevent cancer by strategies utilizing the airway microbiota, as well as summarizing the mechanisms wherein the microbiome acts as a modulator of immunotherapies in lung cancer.
    [Seminars in Cancer Biology]

    Full Article

    Targeting Ferroptosis as a Vulnerability in Pulmonary Diseases

    Scientists discuss the role of ferroptosis in the pathogenesis of pulmonary diseases including asthma, lung injury, lung cancer, fibrotic lung diseases, and pulmonary infection.
    [Cell Death & Disease]

    Full Article

    INDUSTRY AND POLICY NEWS

    Turning Point Therapeutics Provides Regulatory Update for Repotrectinib for the Treatment of ROS1+ Advanced NSCLC

    Turning Point Therapeutics, Inc. announced receipt of positive feedback from the US FDA at a pre-New Drug Application meeting completed within the second quarter.
    [Turning Point Therapeutics, Inc.]

    Press Release

    FEATURED EVENT

    Diet, Nutrition and Cancer Cell Metabolism

    October 24 – 26, 2022
    Madrid, Spain

    > See All Events

    JOB OPPORTUNITIES

    Research Scientist – Inflammation

    Gilead Sciences, Inc. – Foster City, California, United States

    Postdoctoral Fellow – Computational Approaches Focused on the Lung Microbiome

    Wellcome Sanger Institute – Cambridge, England, United Kingdom

    Postdoctoral Scholar – Protein Degradation in Cancer and Alzheimer’s

    Virginia Commonwealth University – Richmond, Virginia, United States

    Postdoctoral Researcher – Brain Metastasis from Lung and Breast Cancers

    Hershey College of Medicine – Hershey, Pennsylvania, United States

    Postdoctoral Fellow – Thoracic Malignancies

    Baylor College of Medicine – Houston, Texas, United States

    > See All Jobs

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