Pulmonary Cell News Volume 11.30 | Aug 4 2022

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    2022-08-04 | PULCN 11.30


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 11.30 – 4 August, 2022
    TOP STORY

    Tumor-Polarized GPX3+ AT2 Lung Epithelial Cells Promote Premetastatic Niche Formation

    By single-cell sequencing, investigators identified a tumor-polarized subpopulation of alveolar type 2 (AT2) epithelial cells with increased expression of glutathione peroxidase 3 (GPX3) and high production of interleukin-10 in the premetastatic niche.
    [Proceedings of the National Academy of Sciences of the United States of America]

    Full Article

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    PUBLICATIONSRanked by the impact factor of the journal

    Ancestral SARS-CoV-2, but Not Omicron, Replicates Less Efficiently in Primary Pediatric Nasal Epithelial Cells

    Researchers used primary nasal epithelial cells (NECs) from children and adults and differentiated at an air–liquid interface to show that the ancestral SARS-CoV-2 replicated to significantly lower titers in the NECs of children compared to those of adults.
    [PLoS Biology]

    Full Article

    Overexpression of Decay Accelerating Factor Mitigates Fibrotic Responses to Lung Injury

    Scientists showed that overexpression of decay accelerating factor in fibrosed lungs limited fibrotic injury by restraining complement dysregulation.
    [American Journal of Respiratory Cell and Molecular Biology]

    Abstract

    House Dust Mite-Induced Akt-ERK1/2-C/Ebp Beta Pathway Triggers CCL20-Mediated Inflammation and Epithelial–Mesenchymal Transition for Airway Remodeling

    To investigate the role of C–C chemokine ligand 20 (CCL20) in chronic airway inflammation and remodeling, researchers made a mouse model of CCL20-induced bronchial asthma.
    [FASEB Journal]

    Full Article

    Transcriptional Responses to Injury of Regenerative Lung Alveolar Epithelium

    The authors mapped all proliferative alveolar epithelial type 2 cells in homeostatic and regenerating murine lungs after injury induced by Streptococcus pneumoniae infection.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Effect of Hyperhomocysteinemia on a Murine Model of Smoke-Induced Pulmonary Emphysema

    A549 cells were cultured with homocysteine and exposed to cigarette smoke extract to observe cell viability and expression of proteins related to the endoplasmic reticulum stress.
    [Scientific Reports]

    Full Article

    Suppression of circXPO1 Attenuates Cigarette Smoke-Induced Inflammation and Cellular Senescence of Alveolar Epithelial Cells in Chronic Obstructive Pulmonary Disease

    Researchers investigated the function and fundamental mechanism of a novel circular RNA XPO1 (circXPO1) in cigarette smoke-induced inflammation and cellular senescence of alveolar epithelial cells.
    [International Immunopharmacology]

    Abstract

    Delivery of Therapeutic miR-148b Mimic via Poly(β Amino Ester) Polyplexes for Post-Transcriptional Gene Regulation and Apoptosis of A549 Cells

    Scientists utilized selectively modified, biodegradable polymer-based polyplexes to deliver custom, exogenous miR-148b mimics to induce apoptosis in human lung cancer (A549) cells.
    [Langmuir]

    AbstractGraphical Abstract

    Measuring Cystic Fibrosis Drug Responses in Organoids Derived from 2D Differentiated Nasal Epithelia

    Investigators described an alternative method of culturing nasal-brushing–derived airway organoids, which were created from an equally differentiated airway epithelial monolayer of a 2D air–liquid interface culture.
    [Life Science Alliance]

    Full Article

    Tumor Necrosis Factor-α Coordinates with Transforming Growth Factor-β1 To Induce Epithelial-Mesenchymal Transition and Migration via the Nf-κB/NOX4 Pathway in Bronchial Epithelial Cells

    Researchers investigated the effect of the proinflammatory cytokine tumor necrosis factor-α on transforming growth factor-β1-induced epithelial-to-mesenchymal transition and the underlying mechanisms in the human bronchial epithelial cell line, BEAS-2B.
    [Molecular Biology Reports]

    Abstract

    Transcriptomic Data Exploration of Consensus Genes and Molecular Mechanisms between Chronic Obstructive Pulmonary Disease and Lung Adenocarcinoma

    Investigators explored the unique and jointly molecular mechanisms in the pathogenesis of COPD and lung adenocarcinoma across several datasets based on a variety of analysis methods.
    [Scientific Reports]

    Full Article

    Curcumin Attenuates Cr (VI)-Induced Cell Growth and Migration by Targeting Autophagy-Dependent Reprogrammed Metabolism

    Cell viability assay on A549 and human embryonic lung fibroblast cells showed that curcumin (Cr) at the concentration of 10 µM could significantly attenuate Cr-induced viability in both cell lines.
    [Journal of Biochemical and Molecular Toxicology]

    Full Article

    The Long Noncoding RNA HOXA11-AS Promotes Lung Adenocarcinoma Proliferation and Glycolysis via the MicroRNA-148b-3p/PKM2 Axis

    The authors showed that HOXA11-AS enhanced lung adenocarcinoma proliferation and glycolysis via the miR-148b-3p/PKM2 axis.
    [Cancer Medicine]

    Full Article

    An informative, visually-compelling wallchart detailing the organization and biology of the respiratory system. Request your copy.
    REVIEWS

    Novel Therapeutic Combinations with PARP Inhibitors for Small Cell Lung Cancer: A Bench-to-Bedside Review

    Investigators summarize existing preclinical evidence supporting inhibitors of the nuclear enzyme poly (ADP-ribose) polymerase (PARP) monotherapy, combination therapy, and respective translation to the clinic.
    [Seminars in Cancer Biology]

    Abstract

    Current Challenges of Unresectable Stage III NSCLC: Are We Ready to Break the Glass Ceiling of the PACIFIC Trial?

    Scientists summarize the current evidence, highlight ongoing trials, and discuss challenges that will ideally lead to a cure for more patients with unresectable stage III NSCLC.
    [Therapeutic Advances in Medical Oncology]

    Full Article

    INDUSTRY AND POLICY NEWS

    Radiopharm Enters into Strategic Collaboration with Lantheus and Assumes Pd-l1 Licensing Agreement from Nanomab

    Radiopharm Theranostics announced that it has entered a collaboration agreement with Lantheus for the development of NM-01, a nanobody made using genetically engineered camelid-derived single domain antibodies, that can be labeled with radioisotopes to potentially diagnose and treat multiple tumor types.
    [Radiopharm Theranostics (Cision US, Inc.)]

    Press Release

    Dosing Completed in Part C of Atossa’s Phase I/IIa Study of AT-H201 in Healthy Volunteers

    Atossa Therapeutics, Inc. announced it has completed dosing participants in Part C of its Phase I/IIa clinical study of its proprietary inhalation therapy. AT-H201 is intended to be inhaled via nebulizer with the goal of preventing lung injury that may be caused by fibrin deposition, fluid build-up, and secondary infection.
    [Atossa Therapeutics, Inc.]

    Press Release

    FEATURED EVENT

    GISM Annual Meeting 2022

    October 20 – 21, 2022
    Turin, Italy

    > See All Events

    JOB OPPORTUNITIES

    Lecturer/Senior Lecturer – Immunomodulation

    King’s College London – London, United Kingdom

    Research Associate Professor – Breast Cancer Metastasis

    Albert Einstein College of Medicine – Bronx, New York, United States

    Research Scientist – Inflammation

    Gilead Sciences, Inc. – Foster City, California, United States

    Postdoctoral Fellow – Computational Approaches Focused on the Lung Microbiome

    Wellcome Sanger Institute – Cambridge, England, United Kingdom

    Postdoctoral Scholar – Protein Degradation in Cancer and Alzheimer’s

    Virginia Commonwealth University – Richmond, Virginia, United States

    > See All Jobs

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