Pulmonary Cell News Volume 13.02 | Jan 18 2024

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    2024-01-18 | PULCN 13.03


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 13.02 – 18 January, 2024
    TOP STORY

    Human Pluripotent Stem Cell Modeling of Alveolar Type 2 Cell Dysfunction Caused by ABCA3 Mutations

    Researchers reported the generation of alveolar type II epithelial cells from affected patient induced pluripotent stem cells carrying homozygous versions of multiple ATP-binding cassette A3 (ABCA3) mutations.
    [European Journal Of Clinical Investigation]

    Full ArticlePress Release
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    Biomimetic Lung-Targeting Nanoparticles with Antioxidative and Nrf2 Activating Properties for Treating Ischemia/Reperfusion-Induced Acute Lung Injury

    The authors developed a biomimetic lung-targeting nanoparticle as an antioxidative lung protector for treating ischemia/reperfusion-induced acute lung injury.
    [Nano Letters]

    AbstractGraphical Abstract

    Alcohol and E-Cigarette Damage Alveolar-Epithelial Barrier by Activation of P2X7r and Provoke Brain Endothelial Injury via Extracellular Vesicles

    Investigators used a model of primary human pulmonary alveolar epithelial cells and exposed the cells to 100 mM ethanol, 100 µM acetaldehyde, or electronic cigarette conditioned media, and measured the mitochondrial efficiency using Agilent Seahorse machine.
    [Cell Communication And Signaling]

    Full Article

    Airway Disease Decreases the Therapeutic Potential of Epithelial Stem Cells

    Researchers determined if airway disease altered the regenerative potential of the human tracheobronchial epithelium obtained by brushing the tracheal mucosa during clinically-indicated bronchoscopy from 48 pediatric and six adult patients.
    [Respiratory Research]

    Full ArticleGraphical Abstract

    Akt Activator SC79 Stimulates Antibacterial Nitric Oxide Generation in Human Nasal Epithelial Cells In Vitro

    Scientists tested effects of SC79 during co-culture of Pseudomonas aeruginosa with primary nasal epithelial cells, using CFU counting and live–dead staining to quantify bacterial killing.
    [International Forum Of Allergy & Rhinology]

    Abstract

    DNA-PK-Mediated Cytoplasmic DNA Sensing Stimulates Glycolysis to Promote Lung Squamous Cell Carcinoma Malignancy and Chemoresistance

    Targeting signaling activated by cytoplasmic DNA sensing with the ZAK inhibitor iZAK2 alone or in combination with STING agonist or anti-PD-1 antibody suppressed the tumor growth and improved the survival of mouse lung cancer models and human lung squamous cell carcinoma patient-derived xenografts model.
    [Cancer Research]

    Abstract

    Plasma Cell-Free DNA Hydroxymethylation Profiling Reveals Anti-PD-1 Treatment Response and Resistance Biology in Non-Small Cell Lung Cancer

    Blood samples were processed to obtain plasma-derived cell-free DNA (cFDNA), followed by enrichment of 5hmC-containing cfDNA fragments through biotinylation via a two-step chemistry and binding to streptavidin coated beads.
    [Journal For Immunotherapy Of Cancer]

    Full Article

    PRKCSH Contributes to TNFSF Resistance by Extending IGF1R Half-Life and Activation in Lung Cancer

    Researchers demonstrated that protein kinase C substrate 80K-H (PRKCSH) abundance in lung cancers boosted oncogenic IGF1R activation, leading to Tumor necrosis factor superfamily (TNFSF) resistance.
    [Experimental & Molecular Medicine]

    Full Article

    Tissue Factor Overexpression Promotes Resistance to KRAS-G12C Inhibition in Non-Small Cell Lung Cancer

    Combination treatment of HuSC1-39 or mTORC1/2 inhibitor MTI-31 with KRASG12C mutation-specific inhibitors sotorasib and adagrasibI each produced synergistic antitumor efficacy in cell culture and in an orthotopic lung tumor model.
    [Oncogene]

    Full Article
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    REVIEWS

    Lung Cancer Oncogene-Directed Therapy, Fertility and Pregnancy

    The authors performed a narrative review of ex-vivo placenta perfusion studies, pharmacologic characteristics, mutagenicity, animal embryo-fetal development studies, and case reports of pathways to motherhood, pregnancies and egg retrieval while on EGFR, ALK or ROS1-targeted therapy.
    [Journal Of Thoracic Oncology]

    Abstract

    Genetically-Engineered Mouse Models of Small Cell Lung Cancer: The Next Generation

    Scientists summarize how genetically-engineered mouse models of SCLC have contributed significantly to our understanding of the disease in the past two decades, as well as recent advances in modeling SCLC in mice that allow investigators to bypass limitations of the previous generation of genetically-engineered mouse models.
    [Oncogene]

    Abstract
    INDUSTRY AND POLICY NEWS

    European Commission Approves Roche’s Tecentriq SC, the EU’s First PD-(L)1 Cancer Immunotherapy Subcutaneous Injection for Multiple Cancer Types

    Until now, Tecentriq has been given directly into patients’ veins by IV infusion which takes approximately 30-60 minutes. The new subcutaneous injection will cut treatment time to approximately seven minutes, with most injections taking between four and eight minutes.
    [Roche]

    Press Release
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    JOB OPPORTUNITIES

    Senior Staff Scientist – Lung Airway/Vascular and Inflammatory Diseases

    University of Florida – West Palm Beach, Florida, United States

    Research Fellow – Structural Biology of RNA

    University of Birmingham – Birmingham, England, United Kingdom

    Postdoctoral Research Associate – Morphogenesis of the Lung and Mammary Gland

    Princeton University – Princeton, New Jersey, United States

    Research Assistant – Lung Stem Cells and Disease

    University of Cambridge – Cambridge, England, United Kingdom

    Postdoctoral Researcher – Computational Cancer Evolution

    Human Technopole – Milan, Italy

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