Pulmonary Cell News Volume 13.12 | Apr 11 2024

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    Noshin Noorjahan
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    2024-04-11 | PULCN 13.12


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 13.12 – 11 April, 2024
    TOP STORY

    Tracing the Origin of Alveolar Stem Cells in Lung Repair and Regeneration

    Researchers introduced a dual recombinase-mediated intersectional genetic lineage tracing approach, enabling precise investigation of alveolar type 2 cellular origins during lung homeostasis, injury, and repair.
    [Cell]

    Full ArticleGraphical Abstract
    Discover new celli Isolation technologies
    PUBLICATIONSRanked by the impact factor of the journal

    Vangl-Dependent Mesenchymal Thinning Shapes the Distal Lung during Murine Sacculation

    Investigators showed that planar cell polarity (PCP) was dispensable in the airway epithelium for sacculation. They found a Celsr1-independent role for the PCP component Vangl in the pulmonary mesenchyme.
    [Developmental Cell]

    AbstractGraphical Abstract

    USP7 Upregulated by TGF-β1 Promotes Ferroptosis via Inhibiting LATS1-YAP Axis in Sepsis-Induced Acute Lung Injury

    Researchers investigated the interactive roles of TGF-β1, ubiquitin-specific-processing protease 7 (USP7), and yes-associated protein (YAP) in ferroptosis during sepsis-secondary acute lung injury.
    [iScience]

    AbstractFull ArticleGraphical Abstract

    Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors

    Using comprehensive genomic profiling among >600,000 patients, the authors identified activating MET tyrosine kinase domain point mutations as putative oncogenic drivers across diverse cancers, with a frequency of ~0.5%.
    [Cancer Discovery]

    Abstract

    Oncogene-Driven Non-Small Cell Lung Cancers in Patients with a History of Smoking Lack Smoking-Induced Mutations

    To better understand the clonal architecture and genomic landscape of non-smoking-related oncogene-driven tumors in smokers compared to typical-smoking NSCLCs, scientists investigated genomic and transcriptomic alterations in 173 tumor sectors from 48 NSCLC patients.
    [Cancer Research]

    Abstract

    DRD1 Suppresses Cell Proliferation and Reduces EGFR Activation and PD-L1 Expression in NSCLC

    Expression and methylation of dopamine receptor D1 (DRD1) were measured using RNAseq and RT-PCR in NSCLC samples and validated using publicly available datasets.
    [Molecular Oncology]

    Full Article
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    REVIEWS

    Cell-Free DNA Methylation in the Clinical Management of Lung Cancer

    Investigators discuss the current state of the art in cell-free (cf)DNA methylation analysis, examine the unique features and limitations of these new methods in a clinical context, propose two models for applying cfDNA methylation data for lung cancer screening, and discuss future research directions.
    [Trends in Molecular Medicine]

    Abstract
    INDUSTRY AND POLICY NEWS

    American Lung Association and LUNGevity Foundation Announce $3 Million Research Partnership to Intercept Lung Cancer

    In a collaborative effort to end lung cancer, the American Lung Association and LUNGevity Foundation have joined forces to invest $3 million over the next three years in research aimed at intercepting lung cancer.
    [American Lung Association]

    Press Release
    FEATURED EVENT

    Microsymposium on RNA Biology

    April 24 – 26, 2024
    Vienna, Austria

    > See All Events

    JOB OPPORTUNITIES

    Postdoc Fellow – Immunology

    Indiana University School of Medicine – Indianapolis, Indiana, United States

    Research Assistant – Cancer Study

    Singapore Institute Of Technology – Singapore, Singapore

    Research Assistant – Biology

    Maynooth University – Maynooth, Ireland

    Posdoctoral Fellow Positions – Epidemiology

    Brigham and Women’s Hospital – Boston, Massachusetts, United States

    Postdoctoral Position – Organoid-Based Systems for Anti-Infective Drug Discovery

    EPFL – Lausanne, Switzerland

    > See All Jobs

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