 | | Vol. 13.19 – 18 July, 2024 |
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| Scientists showed that lung-specialized alveolar fibroblasts took on multiple molecular states with distinct roles in facilitating responses to fibrotic lung injury.
[Nature] |
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 | | PUBLICATIONSRanked by the impact factor of the journal |
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| Researchers administered the fibroblast-selective TGFβ1 signaling inhibitor, epigallocatechin gallate, to interstitial lung disease patients undergoing diagnostic lung biopsy and conducted single-cell RNA sequencing on spare tissue.
[Journal of Clinical Investigation] |
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| | A dose-escalation and expansion, Phase I/II study was conducted to assess the novel antibody-drug conjugate SHR-A1811 in pretreated HER2-altered advanced NSCLC.
[Signal Transduction and Targeted Therapy] |
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| Investigators hypothesized that KEAP1 wild-type tumors recapitulated the transcriptional footprint of KEAP1 mutations and that this KEAPness phenotype could determine immune responsiveness with higher precision compared to mutation-based models.
[Clinical Cancer Research] |
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| The authors investigated patient-derived tumor organoids and matched tumor tissues from surgically treated non-small cell lung cancer patients to identify drug repurposing targets to overcome resistance towards standard-of-care platinum-based doublet chemotherapy.
[Clinical Cancer Research] |
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| Lentivirus-mediated overexpression of NOP2 in vitro resulted in enhanced migration and invasion capabilities of lung cancer cells, while in vivo experiments demonstrated its ability to promote the growth and metastasis of xenograft tumors.
[Cell Death & Disease] |
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| Researchers discovered that protein arginine methyltransferase 1 (PRMT1) was highly expressed under conditions of glucose sufficiency. PRMT1 induced an increase in the PKM2/PKM1 ratio through upregulation of PTBP1, in turn, promoting aerobic glycolysis in NSCLC.
[Cell Death & Disease] |
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| The authors propose a guideline using iPSCs to create all the disease-relevant cell types. iPSCs can be differentiated into lung epithelium, innate immune cells, endothelial cells, and fibroblasts at a large scale, recapitulating in vivo functions and providing genetic tractability.
[Respiratory Research] |
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| Dr. Michelle Mendoza and Dr. Jeffrey Weiss are the recipients of a $2.6 million grant from the National Institutes of Health to research how tension in lung tissue affects the growth and distribution of tumors.
[Huntsman Cancer Institute] |
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| August 19 – 21, 2024
San Diego, California, United States |
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| | Dalhousie University – Halifax, Nova Scotia, Canada |
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| | Cedars-Sinai – Los Angeles, California, United States |
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| | Boston University – Boston, Massachusetts, United States |
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| | Amgen, Inc. – Houston, Texas, United States |
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| | National Cancer Institute – Bethesda, Maryland, United States |
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