 | | Vol. 14.10 – 29 May, 2025 |
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| The authors reported one of the largest integrated analyses to date of sotorasib clinical efficacy biomarkers from the Phase II CodeBreaK 100 and Phase III CodeBreaK 200 studies.
[Nature Medicine] |
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 | | PUBLICATIONSListed by the impact factor of the journal |
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| Using conditional endothelial and epithelial CXCR2 knockout mice, scientists demonstrated that selective CXCR2 deletion in either compartment impairs neutrophil recruitment into the lung during bacterial pneumonia and reduces bacterial clearance.
[Nature Communications] |
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| Researchers characterized nasal airway epithelial cell (NAEC) developmental phenotypes from children aged two to three years in an a priori designed nested birth cohort from four mutually exclusive groups of wheezers/nonwheezers and respiratory syncytial virus–infected/uninfected in the first year of life.
[Science Advances] |
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| Investigators demonstrated that human alveolar macrophages from patients with moderate COPD have reduced ANT1 expression while macrophages from very severe COPD have elevated ANT1 compared to normal control subjects.
[American Journal of Respiratory Cell and Molecular Biology] |
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| Scientists investigated the effects of recombinant inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) against acute lung injury in C57BL/6JNarl and B6.Sftpc-CreERT2;Ai14(RCL-tdT)-D mice exposed to Fe-containing particulate matter.
[Respiratory Research] |
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| In this cohort study of 93 RET+ NSCLC samples and 112 RET wild-type controls, mesenchymal epithelial transition factor receptor immunohistochemistry expression was significantly enriched in RET+ NSCLC.
[JAMA] |
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| Investigators showed that an RNF20-HIF1α axis links the DNA damage response and metabolic reprogramming in lung cancer.
[Nature Communications] |
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| The authors compared gene expression in small cell lung cancer (SCLC) patient samples who never experienced metastasis or relapse throughout their clinical course, versus primary SCLC patient samples from more typical patients who had metastatic disease at diagnosis.
[Nature Communications] |
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| Investigators identified retinoid X receptor γ (RXRγ) as a key driver in the progression of small-cell lung cancer from chemosensitivity to chemoresistance.
[Proceedings of The National Academy of Sciences of The United States of America] |
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| The authors highlight how, with increasing age, the alveolar epithelium becomes vulnerable to exogenous insults.
[Thorax] |
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Cleveland Clinic has been awarded a $5 million grant from the Cystic Fibrosis Foundation to continue its role as the Biorepository Coordinating Center for the Cystic Fibrosis Lung Transplant Consortium until 2030.
[Cleveland Clinic] |
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| July 25-26, 2025
Huntington Beach, California, United States |
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| | University of Leicester – Leicester, England, United Kingdom |
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| | University of Cincinnati – Cincinnati, Ohio, United States |
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| | 3IA Côte d’Azur – Valbonne, France |
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| | Princeton University – Princeton, New Jersey, United States |
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| | University of Newcastle – Callaghan, Australia |
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