Pulmonary Cell News Volume 14.15 | Aug 7 2025

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    Emily Salmini
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    2025-08-07 | PULCN 14.15


    Pulmonary Cell News by STEMCELL Technologies
    Vol. 14.15 – 7 August, 2025
    TOP STORY

    Genetic Variation in the Activity of a TREM2-P53 Signaling Axis Determines Oxygen-Induced Lung Injury
    Using genetically diverse mouse models, scientists found that hyperoxia-sensitive mice exhibit a distinct innate immune response compared to resilient strains.
    [Nature Immunology]
    Abstract
    PUBLICATIONSListed by the impact factor of the journal

    Inhibition of Epithelial Cell YAP-TEAD/LOX Signaling Attenuates Pulmonary Fibrosis in Preclinical Models
    Researchers showed that fibrotic alveolar type II cells regulate production and crosslinking of extracellular matrix via the co-transcriptional activator YAP.
    [Nature Communications]
    Full ArticlePress Release

    Temporo-Spatial Cellular Atlas of the Regenerating Alveolar Niche in Idiopathic Pulmonary Fibrosis
    Using human lung tissue that represents different stages of disease and a 33-plex single-cell imaging mass cytometry, investigators presented a high-resolution, temporo-spatial cell atlas of the regenerating alveolar niche.
    [Nature Communications]
    Full ArticlePress Release

    Atezolizumab and Bevacizumab, with, or without Radiotherapy, Versus Docetaxel in Patients with Metastatic Non-Small Cell Lung Cancer Previously Treated with a Checkpoint Inhibitor, and Chemotherapy: Results from the Randomized, Phase Ib/II MORPHEUS-Lung Study
    Scientists reported robust interim analysis results from the MORPHEUS-Lung study in immune checkpoint inhibitor-exposed patients with non-squamous metastatic NSCLC and without targetable gene mutations.
    [Journal for Immunotherapy of Cancer]
    Full Article

    Neoadjuvant Anti-Programmed Death-1 Immunotherapy by Pembrolizumab in Resectable Non-Small Cell Lung Cancer: Results of the NEOMUN Trial
    The Phase II NEOMUN trial was conducted to investigate the therapeutic effect of preoperative programmed death receptor-1 inhibitor pembrolizumab for treating non-small cell lung cancer.
    [Journal of Immunotherapy of Cancer]
    Full Article

    USP3 Stabilizes MIC19 by Deubiquitination under Hypoxic Stress and Promotes the Progression of Non-Small Cell Lung Cancer
    Researchers investigated the effects of hypoxia on mitochondrial cristae organizing protein 19 (MIC19) and its regulatory mechanisms in NSCLC.
    [Acta Pharmacologica Sinica]
    Abstract
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    REVIEWS

    DNA Damage Response and Cell Fate Decisions across the Lifespan: From Fetal Development to Age-Related Respiratory Diseases
    The authors review the pathogenic mechanisms of DNA damage response in respiratory diseases across the lifespan, including bronchopulmonary dysplasia, bronchial asthma, COPD, and idiopathic pulmonary fibrosis.
    [Cell & Bioscience]
    Full Article
    INDUSTRY AND POLICY NEWS

    MAIA Biotechnology Receives FDA’s Fast Track Designation for Ateganosine as a Treatment for Non-Small Cell Lung Cancer
    MAIA Biotechnology, Inc. announced that the US FDA has granted Fast Track designation for ateganosine for the treatment of NSCLC.
    [MAIA Biotechnology, Inc.]
    Press Release

    NMPA Accepts sNDA for Ivonescimab in Combination with Chemotherapy as First-Line Treatment for Advanced Squamous Non-Small Cell Lung Cancer
    Akeso, Inc. announced that the National Medical Products Administration (NMPA) has accepted the supplementary New Drug Application for ivonescimab in combination with chemotherapy as a first-line treatment for advanced squamous NSCLC.
    [AKeso, Inc (BioSpace)]
    Press Release
    FEATURED EVENT

    Organoids Are Us 2025
    September 23-26, 2025
    Glasgow, Scotland, United Kingdom

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    JOB OPPORTUNITIES

    Research Technician – Pulmonary and Critical Care Medicine
    Washington University – St. Louis, Missouri, United States

    Postdoctoral Fellow – Lung Cancer Initiation
    The Francis Crick Institute – London, England, United Kingdom

    Laboratory Research Technician – Systemic Sclerosis
    University of Pittsburgh – Pittsburgh, Pennsylvania, United States

    Postdoctoral Fellow – Oncology
    Georgetown University – Washington D.C., United States

    PI Positions – Regenerative Biology and Medicine
    The Chinese Institutes for Medical Research (CIMR), Beijing – Beijing, China

    > See All Jobs

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