 | Vol. 14.00 – 15 January, 2025 |
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| The authors demonstrated that AGD1, derived from prostate CSCs, enhanced the stemness of prostate cancer cells and reduced the therapeutic effect of docetaxel in castration-resistant prostate cancer. [Journal of Experimental & Clinical Cancer Research] |
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 | PUBLICATIONSListed by the impact factor of the journal |
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| Investigators identified a cancer cell subpopulation termed stem/transient amplifying-like cells, which expressed genes associated with stem cell-like characteristics and metastatic potential. [Cancer Letters] |
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| Researchers identified a nicotine-triggered pathway regulating the stemness and tumorigenicity of intestinal stem cells and suggested the use of dibenzazepine as a potential therapeutic strategy for treating intestinal tumors. [eLife] |
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| Investigators increased expression of fibronectin type III and SPRY domain-containing 1 (FSD1) or interference with FSD1 phosphorylation reduces microtubule deacetylation, suppresses invasion of glioblastoma (GBM) stem cells, and ultimately mitigates tumor infiltration in orthotopic GBM xenografts. [Science China Life Sciences] |
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| Both musashi 2 (MSI2) and protein kinase D1 (PKD1) ameliorated short hairpin-long noncoding RNA FGD5 antisense RNA 1’s inhibition of hepatocellular carcinoma cell viability, proliferation, and stemness. [Molecular Carcinogenesis] |
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| Scientists elucidated Raddeanin A’s significant antitumor efficacy against glioblastoma in vitro and in vivo by targeting pathways linked to stemness and epithelial-mesenchymal transition, chiefly via the downregulation of S phase kinase-associated protein 2 (Skp2). [Journal of Cancer] |
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| Researchers investigated how arecoline-induced extracellular vesicle secretion suppresses PAX1 protein production through DNA hypermethylation and examined whether PAX1 downregulation enhances cancer stemness and immunosuppression in the tumor microenvironment. [Oral Diseases] |
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| Scientists suggested that targeting of glycosylphosphatidylinositol-specific phospholipase D1 (GPLD1) in colorectal cancer might contribute to a new therapeutic strategy that was based on suppression of Wnt signaling and epithelial-mesenchymal transition-related cancer progression driven by CSCs. [Journal of Biochemistry] |
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| Investigators explored the clinicopathological significance of MRPL24 in human cancers, with a particular focus on breast cancer. [3 Biotech] |
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| B-cell-specific Moloney murine leukemia virus insertion site-1 (Bmi-1) regulates self-renewal, proliferation, and differentiation of glioblastoma cells, promoting stemness and therapy resistance. The authors discuss the importance of targeting Bmi-1 which could be a promising therapeutic target for glioblastoma treatment. [Cancer Medicine] |
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| Eterna Therapeutics announced positive results from a preclinical study on the company’s lead cell therapy product, ERNA-101, which is designed to activate and regulate the immune system’s response to recognize and attack ovarian cancer cells. [Eterna Therapeutics] |
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| February 16-21, 2025 Pomona, California, United States |
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| Anglia Ruskin University – Cambridge, England, United Kingdom |
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| University of California San Francisco – San Francisco, California, United States |
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| University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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| IFOM ETS – The AIRC Institute of Molecular Oncology – Milan, Italy |
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| The University of Pennsylvania – Philadelphia, Pennsylvania, United States |
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