 | | Vol. 14.18 – 16 June, 2022 |
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| Researchers combined human umbilical cord mesenchymal stem cells (hUC-MSCs) with cell sheet technology to evaluate the safety and efficacy of hUC-MSC sheets in preclinical studies using appropriate animal models.
[Stem Cell Research & Therapy] |
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| PUBLICATIONSRanked by the impact factor of the journal |
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| Investigators showed that HucMSCs contributed to cardiac functional recovery and attenuated cardiac remodeling post myocardial infarction. Intramyocardial injection of HucMSCs upregulated the CD4+FoxP3+ Tregs and contributed to the migration of CD4+ T cells into the injured heart via CCL5/CCR5 pathway.
[Stem Cell Research & Therapy] |
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| Researchers discovered a new biological function and underlying molecular mechanisms of growth differentiation factor-11 (GDF-11) in the regulation of human extravillous trophoblast cell invasion.
[Cell Communication and Signaling] |
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| Scientists present a mega-analysis of 14 publicly available placenta DNA methylation microarray datasets to identify individual CpGs and regions associated with fetal sex.
[Scientific Reports] |
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| Investigators suggested that drug transport in BeWo cells can be altered before and after differentiation, and that the altered gabapentin uptake could be mediated by the intracellular amino acid status.
[Xenobiotica] |
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| A comparative analysis of single-cell RNA sequencing data collected from three HUCMSCs and two human umbilical vein endothelial cell controls identified eight common cell clusters, all of which indicated regenerative potential specific for HUCMSCs.
[Nature Cardiovascular Research] |
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| Since angiogenesis plays a critical role in all four stages of normal wound healing, recent therapeutic approaches have focused on utilizing stem cells for inducing neovascularization.
[Wound Repair and Regeneration] |
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| The authors summarize phthalate exposures in relation to an extensive set of placental measures. Phthalate-related alterations were reported for placental morphology, hormone production, vascularization, histopathology, and gene/protein expression.
[Toxicological Sciences] |
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| Rensselaer Polytechnic Institute and the Icahn School of Medicine at Mount Sinai announced the creation of the Center for Engineering and Precision Medicine, one of the first centers in the nation to bridge engineering and engineering science with medicine.
[Icahn School of Medicine at Mount Sinai] |
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| December 8 – 10, 2022
Los Angeles, California, United States |
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| | Albert Einstein College of Medicine – New York, New York, United States |
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| | Luna Genetics, Inc. – Houston, Texas, United States |
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| | Flanders Institute for Biotechnology – Antwerp, Belgium |
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| | New York University College of Dentistry – New York, New York, United States |
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| | Van Andel Institute – Grand Rapids, Michigan, United States |
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