Newsletters

[Cancer Immunology Research] Using single-cell and spatial transcriptomes, scientists identified at the single-cell level, a subpopulation of macrophages related to T cell expansion during immunotherapy, characterized by high temperature requirement A1 (HTRA1) high expression and correlated with clinical and immunotherapy outcomes in TNBC.

[Cell Death Discovery] Researchers investigate how intratumoral lactate accumulation affects NK cell function in breast cancer, a neoplasm characterized by elevated glycolytic flux.

[Journal of agricultural and food chemistry] Investigators determine Citrulline’s impact on milk fat synthesis and clarify its mechanism. They initially examined reticulon 3 (RTN3) expression in the mammary glands of dairy cows with high and low milk fat contents.

[Clinical and Experimental Immunology] Scientists showed that nebivolol reinvigorates CD4⁺ and CD8⁺ T cells following repeated activation, restoring their cytotoxic function against breast cancer cells in vitro.

[Clinical and Experimental Medicine] Researchers explored the function of CXCL12 in tumor metastasis. CXCL12 protein expression levels were assessed by IHC in breast cancer tissues.

[BMC Cancer] HOTAIR lncRNA and EZH2 mRNA expression levels were analyzed to assess their combined value as a predictive marker in breast cancer.

[Journal of Nanobiotechnology] The authors summarize recent advances in hydrogel-based nanomaterials for breast cancer therapy, with emphasis on design strategies, mechanisms of action, and immunomodulatory applications.

[iScience] Scientists position JAK/STAT-driven PD-L1 regulation as a unifying framework for understanding immune evasion and optimizing immunotherapy in breast cancer.

[Molecular Therapy Oncology] The authors explore translational advances in molecular therapies, focusing on conventional antibodies, nanobodies, peptides, and aptamers to target key TNBC molecules.

[Ataraxis AI] Ataraxis AI announced Ataraxis^™ Breast CTX, a new predictive capability within its Ataraxis Breast platform, designed to help estimate individualized chemotherapy benefit in breast cancer patients.

[IJC] The Josep Carreras Leukemia Research Institute (IJC) has welcomed a high-level delegation from the Institute of Hematology & Blood Diseases Hospital. Collaborative efforts will address critical challenges in the field, including the biology of blood cancer stem cells, mechanisms of therapeutic resistance, and the development of next-generation immunotherapies.

[Oncogene] Scientists demonstrate that the ATP-binding cassette transporter A3 (ABCA3) maintains lipid metabolic balance in glioblastoma stem cells. Knocking down ABCA3 significantly reduces cell growth, self-renewal, viability, and tumor growth after intracranial implantation.