Hepatitis E Virus Infects Brain Microvascular Endothelial Cells, Crosses the Blood–Brain Barrier, and Invades the Central Nervous System

By using an in vitro blood–brain barrier (BBB) model, the authors investigated whether Hepatitis E virus (HEV) could cross the BBB and whether the quasi-enveloped HEV virions were more permissible to the BBB than the nonenveloped virions.