C-abl Tyrosine Kinase Inhibition Attenuate Oxidative Stress-Induced Pancreatic β-Cell Dysfunction via Glutathione Antioxidant System

Researchers reported that oxidative stress-driven reduced/oxidized glutathione loss and proteasomal degradation of glutathione peroxidase 4 promoted ferroptotic-like cell damage through increased lipid peroxidation.