Newsletters

[Orca Bio] Orca Bio announced the US FDA has approved TREGZI™, for use in matched-donor hematopoietic stem cell transplantation with myeloablative preparative regimen, for hematopoietic and immunologic reconstitution and to improve chronic graft-versus-host disease-free survival, in the treatment of adults with hematological malignancies.

[Cell Metabolism] The authors describe how redox imbalance breaks tolerance in systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis. They outline targeted strategies that alleviate redox imbalance in autoimmune pathologies.

[Molecular Neurobiology] Scientists examine the mechanistic roles of Tregs in modulating central nervous system (CNS)-resident cells such as microglia, astrocytes, and endothelial cells, with emphasis on their capacity to suppress inflammation and support functional recovery.

[Cell Reports Medicine] Transplantation tolerance, a recipient-centric strategy, utilizes central deletional processes through mixed hematopoietic chimerism and thymic repertoire sculpting, complemented by peripheral mechanisms such as T cell anergy, exhaustion, apoptotic deletion, and Treg dominance.

[Nature Immunology] During a primary infection with Plasmodium, Treg cells suppress protective immunity by inhibiting germinal center reactions, thereby impeding the control of parasitemia.

[Nature Communications] Researchers investigated the therapeutic efficacy of an IL-2 mutein molecule with enhanced receptor specificity and extended half-life in murine models of solid organ transplantation.

[Communications Biology] Scientists unexpectedly found that infusion of CD4+CD25+ Tregs plus IL-2 in lymphocyte-deficient mice causes skin and heart allograft rejection, while IL-2 or Treg alone didnot.

[Cell Death & Disease] Investigators generated a conditional knock-in strain in which a degradation-resistant Regnase-1 mutant (R111A) was selectively expressed in Foxp3+ Tregs as a transgene investigate the roles of Regnase-1 in Tregs.

[Cellular & Molecular Immunology] In a DSS-induced inflammatory bowel disease model in Rag2-/- mice with either naive WT or Fam234a-deficient CD4+ T cells, mice with Fam234a-deficient CD4+ T cells presented milder symptoms of colitis, accompanied by a decreased ratio of Th17/Treg cells.

[ACS Nano] Researchers uncovered a reactive oxygen species-mediated crosstalk between ferroptotic liver cancer cells and hepatic stellate cells that may promote liver fibrosis.

[Nature Communications] Scientists identified AREL1 as a key driver of hepatic stellate cell activation in MASH-related fibrosis and showed that targeted AREL1 silencing with vitamin A–guided nanoparticles significantly reduces liver fibrosis.

[Cancer Research] Using patient-derived organoids (PDOs) and orthotopic HCC xenograft models, investigators uncovered a role for EGFR in lenvatinib resistance.