Early Expression of Mature αβ TCR in CD4⁻CD8⁻ T Cell Progenitors Enables MHC to Drive Development of T-ALL Bearing NOTCH Mutations

Researchers demonstrated that major histocompatibility complex (MHC):T cell antigen receptor signaling could be required to initiate a cancer phenotype from an understudied developmental state that appeared to be represented in the mouse and human disease spectrum.