PI3Kδ Activity Controls Plasticity and Discriminates between EMT and Stemness Based on Distinct TGFβ Signaling

Based on 3D organoid culture of HCC-derived cell lines and AAV8-based protein overexpression in the mouse liver, the authors showed that activity modulation of isoform δ of phosphoinositide 3-kinase (PI3Kδ) controlled differentiation and discriminated between stemness and epithelial to mesenchymal transition (EMT).