ARHGEF2/EDN1 Pathway Participates in ER Stress-Related Drug Resistance of Hepatocellular Carcinoma by Promoting Angiogenesis and Malignant Proliferation

Elevated Rho guanine nucleotide exchange factor 2 (ARHGEF2) accelerated HCC angiogenesis via the EDN1 pathway, enhanced HCC cell proliferation and tumor growth both in vitro and in vivo, and contributed to endoplasmic reticulum (ER) stress-related treatment resistance.