CYP2E1-Dependent Upregulation of SIRT7 Is Response to Alcohol Mediated Metastasis in Hepatocellular Carcinoma

Investigators showed that overexpression of SIRT7 promoted HCC cell migration and EMT while knockdown of SIRT7 showed opposite effects. Mechanistically, they found that SIRT7 suppressed E-Cadherin expression through FOXO3-dependent promoter binding and H3K18 deacetylation.