Gap Junction Intercellular Communication Mediates Cadmium-Induced Apoptosis in Hepatocytes via the Fas/FasL Pathway

Scientists established a cadmium (Cd) poisoning model in vitro by co-culturing Cd-exposed and unexposed hepatocytes and found that 18β-glycyrrhetinic acid, a GJIC inhibitor, could effectively reduce the apoptosis rate of healthy cells co-cultured with apoptotic cells treated with Cd.