Insights on the Antiviral Mechanisms of Action of the TLR1/2 Agonist Pam3CSK4 in Hepatitis B Virus (HBV)-Infected Hepatocytes

Scientists used in vitro models of HBV-infected cells, based on both primary human hepatocytes and the non-transformed HepaRG cell line to investigate the MoA of Pam3SCK4 and identify relevant combinations with other approved or investigational drugs.