Targeting FAPα-Expressing Hepatic Stellate Cells Overcomes Resistance to Anti-angiogenics in Colorectal Cancer Liver Metastasis Models

The authors found that the occurrence of vessel co-option in bevacizumab-resistant colorectal cancer liver metastasis (CRCLM) xenografts was associated with increased expression of fibroblast activation protein alpha in the co-opted hepatic stellate cells (HSCs), which was dramatically attenuated in HSC-specific conditional Fap-knockout mice bearing CRCLM allografts.