Multifunctional mRNA-Based CAR T Cells Display Promising Anti-tumor Activity against Glioblastoma

Investigators generated mouse and human mRNA-based multifunctional T cells co-expressing a multitargeting CAR based on the NKG2D receptor and the pro-inflammatory cytokines IL12 and IFNa2 and assessed their anti-glioma activity in vitro and in vivo.