High-Fat Diet Induced Cyclophilin B Enhances STAT3/lncRNA-PVT1 Feedforward Loop and Promotes Growth and Metastasis in Colorectal Cancer

Investigators showed that high fat diet-induced Cyclophilin B (CypB) enhanced proliferation and metastasis through an inflammation-driven circuit, including Signal Transducer and Activator of Transcription 3 (STAT3)-triggered transcription of lncRNA-PVT1, and its binding with CypB that promoted activation of STAT3.