Newsletters

[Apertura Gene Therapy] The Foundation for Angelman Syndrome Therapeutics (FAST) announced that it has entered into an agreement with Apertura Gene Therapy. Under the agreement, FAST may access TfR1 CapX™, Apertura’s blood-brain barrier-crossing capsid technology, in investigational gene therapy programs designed for the treatment of Angelman syndrome.

[Tickle College of Engineering] Drs. Bryan Good and Colleen Crouch were awarded a three-year, $600,000 grant from the nonprofit Additional Ventures to search for biomarkers in and around the heart in collaboration with pediatric Fontan specialists from the University of Tennessee Health Sciences Center (UTHSC) in Memphis, Tennessee, and the Nationwide Children’s Hospital in Columbus, Ohio.

[Vascular Pharmacology] Evidence from studies of iPSC-derived vascular systems, spanning both two-dimensional differentiation models and three-dimensional organoid platforms, highlights the critical roles of hemodynamic cues, together with metabolic and immune signaling, in driving the coordinated maturation of endothelial and mural compartments.

[European Heart Journal] Scientists investigated the function of Endophilin A2 in blood pressure homeostasis with particular emphasis on elucidating its mechanism in regulating endothelial nitric oxide synthase (eNOS) protein stability.

[Science Advances] Researchers developed a biomimetic coating with dynamic stiffness via layer-by-layer assembly of recombinant humanized type III collagen and cystamine-modified hyaluronic acid, followed by postcrosslinking.

[Advanced Healthcare Materials] Scientists established an in vitro model of the diffuse midline glioma (DMG)-blood–brain–tumor barrier, comprised of patient-derived DMG tumor cells and primary human brain microvascular endothelial cells, astrocytes, and vascular pericytes, embedded in a fibrin matrix within a microfluidic chip.

[Blood] Single cell RNA-sequencing of endothelial cells (ECs) isolated from a graft-versus-host-disease target organ, the liver, showed rapid, subset-specific transcriptional reprogramming after allogeneic hematopoietic cell transplant, with induction of canonical interferon-γ-inducible genes including interferon regulatory factor 1, MHC II, and PD-L1 in lymphatic ECs.

[Journal of Advanced Research] Scientists investigate whether Puerarin protects against doxorubicin-induced endotheliotoxicity by targeting dimethylarginine dimethylamino- hydrolase 2 (DDAHⅡ). They explored the interplay among nitric oxide signaling, autophagy, and ferroptosis in this process.

[Angiogenesis] The authors investigated the 3D architecture of clear cell renal cell carcinoma (ccRCC) vasculature within the tumor microenvironment and its response to drugs. They defined key features and heterogeneity of ccRCC vascular architecture and highlighted ponds as candidate contributors to treatment failure and targets for future interventions.

[Nature Cardiovascular Research] Scientists used a heterotopic heart transplantation model, in which the donor heart is vascularized but nonpumping, to show that mechanical unloading induces adult cardiomyocyte proliferation, revealed by Ki67-based and mosaic analysis with double markers lineage tracing.

[Acta Pharmacologica Sinica] The authors identified that OTU domain-containing protein 7B (OTUD7b) expression was significantly elevated in cardiomyocytes from both type 1 and type 2 diabetic mouse hearts.

[Life Sciences] Investigators aimed of the study was to rescue obesity induced skeletal muscle atrophy with ascorbic acid in vitro. Their findings suggest that ascorbic acid alleviates adipocyte-derived inflammatory stress and protects against myotube atrophy.