Newsletters

[Proceedings of The National Academy of Sciences of The United States of America] Investigators utilized mouse models of epidermal Mfsd2a deficiency, histological and gene expression analysis, untargeted lipidomics, and human keratinocyte cultures, demonstrating that the epidermal keratinocytes acquire plasma-derived LPC via Mfsd2a mediated transport.

[Cell Death & Disease] Scientists provided evidence for the involvement of necroptosis in psoriasis. Receptor interacting protein kinase 1 (RIPK1) and mixed lineage kinase domain-like pseudokinase (MLKL) were significantly upregulated and localized in all layers of the epidermis in human psoriatic lesions, while RIPK3 and phosphorylated MLKL were mainly expressed in keratinocytes, which were located in the upper layers.

[International Journal of Biological Macromolecules] Researchers developed injectable photo-cured methacrylated collagen-keratin interpenetrating network hydrogels for rapid enhanced wound healing.

[Journal of Ethnopharmacology] Investigators elucidated the potential mechanism of a traditional therapy for vitiligo and identified CASP7 and EP300 as potential key targets. Fufang Baizhi Tincture likely exerts its protective effects by modulating these targets to regulate melanocyte apoptosis and transcription, providing a robust scientific basis for its clinical application.

[Scientific Reports] Researchers examined the therapeutic potential of the neuropeptides neurotensin and substance P in reshaping inflammatory and microbial dynamics and accelerating wound closure in healthy and streptozotocin-induced diabetic mice models.

[Nature] Investigators characterized the genome and transcriptome of 123 acral melanoma tumours from 92 Mexican patients—a population notable because of its genetic admixture9.

[Proceedings of The National Academy of Sciences of The United States of America] The authors found that a specific protein, lamin B receptor (LBR), gets overproduced in aggressive melanoma.

[Journal of Nanobiotechnology] Researchers developed a biocompatible, ROS-responsive hydrogel platform for the local delivery of miR-665, which effectively attenuated inflammatory signaling and stimulated hair follicle regeneration in alopecia areata.

[Scientific Reports] Scientists used several pharmacological inhibitors to extend our understanding of Salinomycin-induced autophagy and its interactions with regulatory proteins, including the anticancer mechanism in cisplatin-resistant melanoma.

[Cancer Letters] The authors synthesize the evolving biomarker landscape across genetic, immune, proteomic, and digital/imaging biomarkers. They highlight subtype-specific differences in mucosal, acral, and uveal melanoma, where biomarker patterns and therapeutic responses diverge markedly from those of cutaneous disease.

[Galderma] Galderma announced new data from the OLYMPIA open-label extension study investigating the long-term safety and efficacy of Nemluvio in moderate-to-severe prurigo nodularis.

[A2 Biotherapeutics, Inc.] A2 Biotherapeutics, Inc. announced the first patient dosed with A2B543, an autologous CAR T cell therapy, initiating the second arm of the Phase I/II EVEREST-2 study.