Role of Human Aldo-Keto Reductases and Nuclear Factor Erythroid 2-Related Factor 2 in the Metabolic Activation of 1-Nitropyrene via Nitroreduction in Human Lung Cells

Researchers used a combination of pharmacological and genetic approaches to assess the relative importance of these enzymes and nuclear factor erythroid 2-related factor 2 in the aerobic nitroreduction of 1-Nitropyrene in human bronchial epithelial cells, A549 and HBEC3-KT.