HIV-1 Remission and Possible Cure in a Woman after Haplo-Cord Blood Transplant
Scientists reported the first remission and possible HIV-1 cure in a mixed-race woman who received a CCR5Δ32/Δ32 haplo-cord transplant, cord blood cells combined with haploidentical stem cells from an adult, to treat acute myeloid leukemia.
[89bio, Inc.] 89bio, Inc. announced positive topline data from the Phase IIb ENLIVEN trial evaluating treatment with pegozafermin in patients with NASH. In the study, both the 44mg Q2W and 30mg QW doses met, with high statistical significance.
[Communications Biology] The expression of myocardial infarction-associated transcript (MIAT) was up-regulated during liver fibrosis. Silencing MIAT led to the suppression of hepatic stellate cell proliferation and collagen expression.
[EMBO Molecular Medicine] WD-repeat 6 (WDR6) deficiency in hepa1-6 cells drastically inhibited the growth and lung metastasis of orthotopically implanted tumors in immune-competent C57BL/6J mice.